Product Info Summary
SKU: | A10882-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Monkey |
Host: | Rabbit |
Application: | ELISA, IHC, WB |
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Product info
Product Name
Anti-PP4R2 PPP4R2 Antibody
SKU/Catalog Number
A10882-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-PP4R2 PPP4R2 Antibody catalog # A10882-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-PP4R2 PPP4R2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10882-1)
Host
Rabbit
Contents
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human PP4R2
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A10882-1 is reactive to PPP4R2 in Human, Monkey
Applications
A10882-1 is guaranteed for ELISA, IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
46898 MW
Background of PPP4R2
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Hastie C.J., Biochem. J. 347:845-855(2000).
Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Validation Images & Assay Conditions
![a10882 1 anti pp4r2 ppp4r2 antibody wb testing 1 a10882 1 anti pp4r2 ppp4r2 antibody wb testing 1](https://www.bosterbio.com/media/catalog/product/a/1/a10882-1-anti-pp4r2-ppp4r2-antibody-wb-testing-1.jpg)
Click image to see more details
Figure 1. Western blotting validation for Anti-PP4R2 PPP4R2 Antibody A10882-1
Western Blot (WB) analysis of K562 cells using PP4R2 polyclonal antibody.Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration
Protein Target Info & Infographic
Gene/Protein Information For PPP4R2 (Source: Uniprot.org, NCBI)
Gene Name
PPP4R2
Full Name
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Weight
46898 MW
Superfamily
PPP4R2 family
Alternative Names
MGC131930; PP4R2; protein phosphatase 4, regulatory subunit 2; serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 PP4R2 protein phosphatase 4 regulatory subunit 2 serine/threonine-protein phosphatase 4 regulatory subunit 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PPP4R2, check out the PPP4R2 Infographic
![PPP4R2 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PPP4R2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PP4R2 PPP4R2 Antibody (A10882-1)
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No publications found for A10882-1
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