PPP4R2 Antibodies

AND PPP4R2 ELISA kits, PPP4R2 Proteins

Many biological assays use antibodies to detect PPP4R2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP4R2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP4R2 antibodies...

We validate the specificity of these antibodies to PPP4R2 by testing them on tissues known to express PPP4R2 positively and negatively. Browse below to find the PPP4R2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PPP4R2 Infographic by Boster Bio

All PPP4R2 Products

Product

Figures

Specificity

Applications

Price

Anti-PP4R2 PPP4R2 Antibody

3 Q&As

Human, Mouse

$360
Cat # A10882
100 µl

Anti-PP4R2 PPP4R2 Antibody

Human, Monkey

ELISA, IHC, WB

$380
Cat # A10882-1
100ul

PPP4R2 Overview

Facts about Serine/threonine-protein phosphatase 4 regulatory subunit 2.

PPP4R2 3D structure. Source: alphafold

Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)

Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the action of PPP4C at centrosomal microtubule organizing centers.

Its interaction with the SMN complex contributes to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.

Gene Information

Human
Gene Name:	PPP4R2
Uniprot:	Q9NY27
Entrez:	151987

Family

Belongs to:

PPP4R2 family

Alternative Names

MGC131930; PP4R2; protein phosphatase 4, regulatory subunit 2; serine/threonine-protein phosphatase 4 regulatory subunit 2

Molecular Weight

Mass (kDA):
46.898 kDA

Genomic Context


Human

Location:	3p13
Sequence:	3; NC_000003.12 (72996743..73069201)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2.

Diseases

Adrenal Hyperplasia
Congenital Abnormality
Developmental Delay (disorder)
Muscular Atrophy
Atrophy
Chromosome Inversion
Loss Of Chromosome 3
Developmental Disabilities
Congenital Adrenal Hyperplasia
Chronic Active Hepatitis

Cytogenetic Abnormality
Hyperplasia
Cleft Lip
Spinal Muscular Atrophy

Interacting Proteins

PPP4C

Pathways

Cell Differentiation
Localization

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP4R2

References

PMID: 10769191 by Hastie C.J., et al. A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres.

PMID: 12668731 by Carnegie G.K., et al. Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs.