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Product Info Summary
| SKU: | P07956 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | IF, IHC, WB |
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Product info
Product Name
Anti-Phospho-p56Dok-2 (Tyr299) Antibody
SKU/Catalog Number
P07956
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Phospho-p56Dok-2 (Tyr299) Antibody (Catalog # P07956). Tested in WB, IHC, IF applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Phospho-p56Dok-2 (Tyr299) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P07956)
Host
Rabbit
Contents
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Immunogen
Peptide sequence around phosphorylation site of tyrosine 299 (G-E-Y(p)-A-V) derived from Human p56Dok-2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
P07956 is reactive to DOK2 in Human
Reconstitution
Calculated molecular weight
45379 MW
Background of DOK2
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation
Feng Cong, et,al. (1999) Mol. Cell. Biol ; 19: 8314 - 8325.
Serge Lemay, et,al. (2000) Mol. Cell. Biol ; 20: 2743 - 2754.
Ute Schaeper, et,al.(2000) J. Cell Biol ; 149: 1419.
Miyuki Honma, et,al. (2006) Genes Cells; 11: 143 - 151.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
P07956 is guaranteed for IF, IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Predicted MW: 56kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
Validation Images & Assay Conditions
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Western blot analysis of extracts from JK cells, treated with G-CSF or calf intestinal phosphatase (CIP), using p56Dok-2 (Phospho-Tyr299) antibody P07956.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p56Dok-2(Phospho-Tyr299) antibody P07956(left) or the same antibody preincubated with blocking peptide(right).
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Western blot analysis of extracts from Jurkat cells untreated or treated with insulin using p56Dok-2(Phospho-Tyr299) antibody P07956.
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Immunofluorescence staining of methanol-fixed Hela cells using p56Dok-2(Phospho-Tyr299) antibody P07956.
Protein Target Info & Infographic
Gene/Protein Information For DOK2 (Source: Uniprot.org, NCBI)
Gene Name
DOK2
Full Name
Docking protein 2
Weight
45379 MW
Superfamily
DOK family
Alternative Names
Docking protein 2;Downstream of tyrosine kinase 2;p56 (dok-2);DOK2; DOK2 p56DOK, p56dok-2 docking protein 2 docking protein 2|docking protein 2, 56kD|docking protein 2, 56kDa|downstream of tyrosine kinase 2|p56(dok-2)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DOK2, check out the DOK2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DOK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-p56Dok-2 (Tyr299) Antibody (P07956)
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