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Docking protein 2 Antibodies
AND DOK2 ELISA kits, Docking protein 2 Proteins
Many biological assays use antibodies to detect Docking protein 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Docking protein 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Docking protein 2 antibodies...
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DOK2 Infographic by Boster Bio
All DOK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1427
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1427
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2387
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2387
1 kit, containing two 96-well plates and all necessary reagents
Human
Flow Cytometry, IF, WB
$523
Cat # M07956
100 µl
Cat # M07956
100 µl
Dog, Human, Monkey, Mouse, Rat
WB
$523
Cat # M07956-1
100 µl
Cat # M07956-1
100 µl
DOK2 Overview
Facts about Docking protein 2.
Docking protein 2 (DOK2)
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes.
DOK2 may regulate the cellular proliferation induced by IL-4, in addition to IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | DOK2 |
| Uniprot: | O60496 |
| Entrez: | 9046 |
Family
| Belongs to: |
|---|
| DOK family |
Alternative Names
docking protein 2; docking protein 2, 56kD; docking protein 2, 56kDa; Dok-2; Downstream of tyrosine kinase 2; p56(dok-2); p56DOK; p56dok-2
Molecular Weight
Mass (kDA):
45.379 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.3 |
| Sequence: | 8; NC_000008.11 (21908873..21913717, complement) |
Tissue Specificity
Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver.
Diseases
- Leukemia
- Neoplasms
- Myeloid Leukemia
- Myeloid Leukemia, Chronic
- Malignant Neoplasms
- Stomach Neoplasms
- Sarcoma
- Immunologic Deficiency Syndromes
- Adenocarcinoma
- Haploinsufficiency
- Liver Neoplasms
- Adenocarcinoma Of Lung (disorder)
- Leukemogenesis
Interacting Proteins
- POT1
Pathways
- Cell Activation
- Cytokine Production
- Pathogenesis
- Cell Proliferation
- Cell Migration
- T Cell Activation
- Mast Cell Activation
- Immune Response
- Hypersensitivity
- Localization
- Mast Cell Degranulation
- Cell Adhesion
- Platelet Activation
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DOK2
bosterbio.com/bosterbio-gene-info-cards/DOK2
References
PMID: 9478921 by Di Cristofano A., et al. Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins.
PMID: 28841444 by Lahmidi S., et al. Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2.