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Product Info Summary
| SKU: | A02516-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-PDCD5 Antibody
SKU/Catalog Number
A02516-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-PDCD5 Antibody (Catalog # A02516-2). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PDCD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-PDCD5 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02516-2)
Host
Rabbit
Contents
PDCD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PDCD5 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5. The immunogen is located within the first 50 amino acids of PDCD5.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.
Reactive Species
A02516-2 is reactive to PDCD5 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
21 kDa
Calculated molecular weight
14,285 MW
Background of PDCD5
Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02516-2 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PDCD5 antibody can be used for detection of PDCD5 by Western blot at 2.5 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PDCD5 in Jurkat cell lysate with PDCD5 antibody at 2.5 μg/mL.
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Immunocytochemistry of PDCD5 in Jurkat cells with PDCD5 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PDCD5 (Source: Uniprot.org, NCBI)
Gene Name
PDCD5
Full Name
Programmed cell death protein 5
Weight
14,285 MW
Superfamily
PDCD5 family
Alternative Names
FLJ42784; MGC9294; PD5; PDCD5; programmed cell death 5; programmed cell death protein 5; Protein TFAR19; TF-1 cell apoptosis-related protein 19; TFAR19 novel apoptosis-related; TFAR19; TFAR19TF1 cell apoptosis-related gene 19 PDCD5 TFAR19 programmed cell death 5 programmed cell death protein 5|TF-1 cell apoptosis-related protein 19|TF1 cell apoptosis-related gene 19|TFAR19 novel apoptosis-related
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PDCD5, check out the PDCD5 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PDCD5: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-PDCD5 Antibody (A02516-2)
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