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Key=meta_title, value=Oncostatin M/OSM Antibody
Key=meta_description, value=Boster Bio Anti-Oncostatin M/OSM Antibody catalog # PA1668. Tested in IHC, WB applications. This antibody reacts with Human. Supplied as 100μg/vial in Lyophilized form antibody.
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Key=image_label, value=Anti-Oncostatin M antibody, PA1668, Western blotting
Lane 1: A549 Cell Lysate
Lane 2: A549 Cell Lysate
Lane 3: HELA Cell Lysate

Key=small_image_label, value=Anti-Oncostatin M antibody, PA1668, Western blotting
Lane 1: A549 Cell Lysate
Lane 2: A549 Cell Lysate
Lane 3: HELA Cell Lysate

Key=thumbnail_label, value=Anti-Oncostatin M antibody, PA1668, Western blotting
Lane 1: A549 Cell Lysate
Lane 2: A549 Cell Lysate
Lane 3: HELA Cell Lysate

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Key=size, value=100 μg/vial
Key=protein_name, value=Oncostatin-M(OSM)
Key=gene_full_name, value=Oncostatin-M
Key=uniprot_id, value=P13725
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=IHC, WB
Key=reactivity, value=Human
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Key=predicted_reactivity
Key=source_company, value=Boster PA1668
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=28484 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Cytokines, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, Interleukins, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway
Key=clonality, value=Polyclonal
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Key=description, value=Boster Bio Anti-Oncostatin M/OSM Antibody catalog # PA1668. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-Oncostatin M/OSM Antibody catalog # PA1668. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-Oncostatin M/OSM Antibody
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Key=background, value=OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
Key=gene_name, value=OSM
Key=synonyms, value=Oncostatin-M;OSM;OSM;
Key=application_details, value=Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Key=subcellular_localization, value= Secreted.
Key=sequence_similarities, value=Contains 1 FAD-binding FR-type domain.
Key=tissue_specificity, value= Detected in neutrophils (at protein level). .
Key=protein_function, value= Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity). .
Key=application_notes, value=Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 27104|sc 50294|sc 5488|sc 374040|sc 373734|sc 133229|sc 374039|sc 129|sc 50296|sc 365136|sc 390253
Key=immunogen, value=A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=28 kDa
Key=custom_attribute_2, value=WB: A549 Whole Cell, A549 Whole Cell, HELA Whole Cell
IHC: Human Intestinal Cancer Tissue
Key=custom_attribute_3, value=BA4706
Key=description_after_attributes, value=

Customer Reviews

Source: Biocompare.com

"This NOX2 antibody is highly specific. Highly recommended!"

--RAHUL KUMAR, PHARMACEUTICAL SCIENCES, UNIVERSITY OF COLORADO DENVER, POST DOC

Applications Western Blot
Sample 22RV1 cytosolic and membrane fractions
Detection Enhanced chemiluminescence

"We used this antibody to study the inhibitory effect of GPE on hypoxia induced translocation of gp91phox subunit from cytosol to membrane in our recently published paper (Scientific Reports 6, Article number: 23135 (2016); doi:10.1038/srep23135). This antibody is very much specific in our in vitro system."


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Anti-Oncostatin M/OSM Antibody Picoband®

Oncostatin M/OSM antibody

Boster Bio Anti-Oncostatin M/OSM Antibody catalog # PA1668. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance. Cited in 1 publication(s).

Product Info Summary

SKU: PA1668
Size: 100 μg/vial
Reactive Species: Human
Host: Rabbit
Application: IHC, WB

Product Name

Anti-Oncostatin M/OSM Antibody Picoband®

View all Oncostatin M/OSM Antibodies

SKU/Catalog Number

PA1668

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Oncostatin M/OSM Antibody catalog # PA1668. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Oncostatin M/OSM Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1668)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1668 is reactive to OSM in Human

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

28 kDa

Calculated molecular weight

28484 MW

Background of Oncostatin M/OSM

OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Applications

PA1668 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human

Positive Control

WB: A549 Whole Cell, A549 Whole Cell, HELA Whole Cell
IHC: Human Intestinal Cancer Tissue

Validation Images & Assay Conditions

Gene/Protein Information For OSM (Source: Uniprot.org, NCBI)

Gene Name

OSM

Full Name

Oncostatin-M

Weight

28484 MW

Superfamily

LIF/OSM family

Alternative Names

Oncostatin-M;OSM;OSM; OSM oncostatin M oncostatin-M

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on OSM, check out the OSM Infographic

OSM infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for OSM: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

PA1668 has been cited in 1 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Zhu M, Che Q, Liao Y, Wang H, Wang J, Chen Z, Wang F, Dai C, Wan X. Oncol Rep. 2015 Jul;34(1):129-38. Doi: 10.3892/Or.2015.3951. Epub 2015 May 5. Oncostatin M Activates Stat3 To Promote Endometrial Cancer Invasion And Angiogenesis.

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7 Customer Q&As for Anti-Oncostatin M/OSM Antibody Picoband®

Question

Would PA1668 anti-Oncostatin M/OSM antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2020-05-04

Answer

You can see on the product datasheet, PA1668 anti-Oncostatin M/OSM antibody as been validated on WB. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2020-05-04

Question

I was wanting to use your anti-Oncostatin M/OSM antibody for WB for human t-cell on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human t-cell identification?

Verified Customer

Verified customer

Asked: 2019-08-30

Answer

You can see on the product datasheet, PA1668 anti-Oncostatin M/OSM antibody has been tested for IHC, WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human t-cell in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2019-08-30

Question

Is a blocking peptide available for product anti-Oncostatin M/OSM antibody (PA1668)?

Verified Customer

Verified customer

Asked: 2019-07-02

Answer

We do provide the blocking peptide for product anti-Oncostatin M/OSM antibody (PA1668). If you would like to place an order for it please contact [email protected] and make a special request.

Boster Scientific Support

Answered: 2019-07-02

Question

Would anti-Oncostatin M/OSM antibody PA1668 work on monkey WB with lung?

Verified Customer

Verified customer

Asked: 2019-04-19

Answer

Our lab technicians have not tested anti-Oncostatin M/OSM antibody PA1668 on monkey. You can run a BLAST between monkey and the immunogen sequence of anti-Oncostatin M/OSM antibody PA1668 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated monkey samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in monkey lung in WB, you can get your next antibody for free.

Boster Scientific Support

Answered: 2019-04-19

Question

I see that the anti-Oncostatin M/OSM antibody PA1668 works with WB, what is the protocol used to produce the result images on the product page?

R. Johnson

Verified customer

Asked: 2019-04-04

Answer

You can find protocols for WB on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]

Boster Scientific Support

Answered: 2019-04-04

Question

Is there a BSA free version of anti-Oncostatin M/OSM antibody PA1668 available?

Verified Customer

Verified customer

Asked: 2018-05-15

Answer

Thanks for your recent telephone inquiry. I can confirm that some lots of this anti-Oncostatin M/OSM antibody PA1668 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.

Boster Scientific Support

Answered: 2018-05-15

Question

Please see the WB image, lot number and protocol we used for t-cell using anti-Oncostatin M/OSM antibody PA1668. Please let me know if you require anything else.

Verified Customer

Verified customer

Asked: 2018-03-19

Answer

Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.

Boster Scientific Support

Answered: 2018-03-19

Order DetailsPrice
PA1668

100μg

$370
PA1668-10ug

10μg sample (liquid)

$99
PA1668-Biotin

100 μg Biotin conjugated

$570
PA1668-Cy3

100 μg Cy3 conjugated

$570
PA1668-Dylight488

100 μg Dylight488 conjugated

$570
PA1668-Dylight550

100 μg Dylight550 conjugated

$570
PA1668-Dylight594

100 μg Dylight594 conjugated

$570
PA1668-FITC

100 μg FITC conjugated

$570
PA1668-HRP

100 μg HRP conjugated

$570
PA1668-APC

100 μg APC conjugated

$670
PA1668-PE

100 μg PE conjugated

$670
PA1668-iFluor647

100 μg iFluor647 conjugated

$670
PA1668-carrier-free

Carrier Free

$370

More conjugates/formats

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PA1668
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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