Product Info Summary
SKU: | P07769 |
---|---|
Size: | 100 µl |
Reactive Species: | Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Phospho-NMDA Receptor NR2C Subunit (Ser1096) Antibody
SKU/Catalog Number
P07769
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Phospho-NMDA Receptor NR2C Subunit (Ser1096) Antibody (Catalog # P07769). Tested in WB applications. This antibody reacts with Mouse, Rat.
Storage & Handling
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Cite This Product
Anti-Phospho-NMDA Receptor NR2C Subunit (Ser1096) Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P07769)
Host
Rabbit
Contents
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser1096 of the NR2C subunit of the rat NMDA receptor, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
P07769 is reactive to GRIN2C in Mouse, Rat
Reconstitution
Restore with deionized water (or equivalent) for reconstitution volume of 100 µL
Observed Molecular Weight
52 kDa
Calculated molecular weight
134209 MW
Background of NMDAR2C
The ion channels activated by glutamate that are sensitive to N-methyl-Daspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser-1096 by PKB on NR2C has been recently demonstrated to regulate NMDA receptor binding to 14-3-3 (Chen & Roche 2009)
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
P07769 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
Validation Images & Assay Conditions
Click image to see more details
Western blot of mouse brain lysate showing specific immunolabeling of the ~140 kDa NR2C subunit of the NMDA receptor phosphorylated at Ser1096 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is blocked by preadsorption of the phosphopeptide used as the antigen, but not by the corresponding non-phosphopeptide (not shown).
Protein Target Info & Infographic
Gene/Protein Information For GRIN2C (Source: Uniprot.org, NCBI)
Gene Name
GRIN2C
Full Name
Glutamate receptor ionotropic, NMDA 2C
Weight
134209 MW
Superfamily
glutamate-gated ion channel (TC 1.A.10.1) family
Alternative Names
GluN2C antibody, Glutamate [NMDA] receptor subunit epsilon-3 antibody, Glutamate Receptor Ionotropic N Methyl D Aspartate 2C antibody, Glutamate receptor ionotropic NMDA 2C antibody, Glutamate receptor ionotropic N methyl D aspartate 2C antibody, Grin2c antibody, Grin 2c antibody, GRIN2C antibody, GRIN 2C antibody, N Methly D Aspartate Receptor Channel Subunit Epsilon 3 antibody, N Methyl D Aspartate Receptor Subtype 2C antibody, N methyl D aspartate receptor subunit 2C antibody, N-methyl D-aspartate receptor subtype 2C antibody, NMDAR2C antibody, NMDE3_HUMAN antibody, NR2C antibody, OTTHUMP00000041930 antibody GRIN2C GluN2C, NMDAR2C, NR2C glutamate ionotropic receptor NMDA type subunit 2C glutamate receptor ionotropic, NMDA 2C|N-methyl D-aspartate receptor subtype 2C|N-methyl-D-aspartate receptor subunit 2C|glutamate [NMDA] receptor subunit epsilon-3|glutamate receptor, ionotropic, N-methyl D-aspartate 2C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRIN2C, check out the GRIN2C Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRIN2C: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-NMDA Receptor NR2C Subunit (Ser1096) Antibody (P07769)
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