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- Table of Contents
Facts about Glutamate receptor ionotropic, NMDA 2C.
Sensitivity to glutamate and channel kinetics are determined by the subunit composition (Probable). Plays a role in controlling the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex.
Human | |
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Gene Name: | GRIN2C |
Uniprot: | Q14957 |
Entrez: | 2905 |
Belongs to: |
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glutamate-gated ion channel (TC 1.A.10.1) family |
glutamate [NMDA] receptor subunit epsilon-3; glutamate receptor, ionotropic, N-methyl D-aspartate 2C; GRIN2C; NMDA R, NR2C Subunit; NMDAR2C; NMDAR2CNR2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; NR2C
Mass (kDA):
134.209 kDA
Human | |
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Location: | 17q25.1 |
Sequence: | 17; NC_000017.11 (74842021..74860843, complement) |
Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
PMID: 9037519 by Lin Y.J., et al. Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery.
PMID: 21300787 by Cai L., et al. Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).