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Product Info Summary
| SKU: | M00489-1 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Mouse, Rat |
| Host: | Rabbit |
| Application: | WB |
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Product info
Product Name
Anti-Mouse Mertk Antibody (C-term)
SKU/Catalog Number
M00489-1
Size
80 µl
Description
Boster Bio Anti-Mouse Mertk Antibody (C-term) (Catalog # M00489-1). Tested in WB application(s). This antibody reacts with Mouse, Rat.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-Mouse Mertk Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00489-1)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This Mouse Mertk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 946-980 amino acids from the C-terminal region of mouse Mertk.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M00489-1 is reactive to Mertk in Mouse, Rat
Reconstitution
Calculated molecular weight
110157 Da
Background of Mer
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M00489-1 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
Validation Images & Assay Conditions
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All lanes : Anti-Mertk Antibody (C-term) at 1:2000 dilution
Lane 1: mouse kidney lysates
Lane 2: mouse liver lysates
Lane 3: NIH/3T3 whole cell lysates
Lane 4: rat kidney lysates
Lane 5: rat liver lysates
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size : 110 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
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Anti-Mertk Antibody (C-term) at 1:1000 dilution + mouse spleen lysates
Lysates/proteins at 20 µg per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size : 110 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
Protein Target Info & Infographic
Gene/Protein Information For Mertk (Source: Uniprot.org, NCBI)
Gene Name
Mertk
Full Name
Tyrosine-protein kinase Mer
Weight
110157 Da
Superfamily
protein kinase superfamily
Alternative Names
Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mertk, Mer MERTK MER, RP38, Tyro12, c-Eyk, c-mer MER proto-oncogene, tyrosine kinase tyrosine-protein kinase Mer|MER receptor tyrosine kinase|STK kinase|c-mer proto-oncogene tyrosine kinase|proto-oncogene c-Mer|receptor tyrosine kinase MerTK
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Mertk, check out the Mertk Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Mertk: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Mouse Mertk Antibody (C-term) (M00489-1)
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