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Product Info Summary
| SKU: | A02577 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Livin BIRC7 Antibody
SKU/Catalog Number
A02577
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Livin BIRC7 Antibody (Catalog # A02577). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
Livin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Livin BIRC7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02577)
Host
Rabbit
Contents
Livin Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Livin antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Livin. The immunogen is located within the last 50 amino acids of Livin.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
A lower but much weaker band at 30 kDa was detected in Raji cell lysate, which may represent the short form of Livin.
Reactive Species
A02577 is reactive to BIRC7 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
32798 MW
Background of Livin
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02577 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Livin antibody can be used for detection of Livin by Western blot at 0.5 μg/mL. A band at 33 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Livin expression in human Raji cell lysate with Livin antibody at 0.5 μg/mL.
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Immunohistochemistry of Livin in human small intestine tissue with Livin antibody at 5 μg/mL.
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Immunofluorescence of Livin in Human Small Intestine cells with Livin antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For BIRC7 (Source: Uniprot.org, NCBI)
Gene Name
BIRC7
Full Name
Baculoviral IAP repeat-containing protein 7
Weight
32798 MW
Superfamily
IAP family
Alternative Names
KIAP, LIVIN, MLIAP, RNF50, ML-IAP, KIAP, UNQ5800/PRO19607/PRO21344, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein BIRC7 KIAP, LIVIN, ML-IAP, MLIAP, RNF50 baculoviral IAP repeat containing 7 baculoviral IAP repeat-containing protein 7|RING finger protein 50|RING-type E3 ubiquitin transferase BIRC7|kidney inhibitor of apoptosis protein|livin inhibitor of apoptosis|melanoma inhibitor of apoptosis protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on BIRC7, check out the BIRC7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BIRC7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Livin BIRC7 Antibody (A02577)
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