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BIRC7 Antibodies
AND BIRC7 ELISA kits, BIRC7 Proteins
Many biological assays use antibodies to detect BIRC7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BIRC7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BIRC7 antibodies...
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BIRC7 Infographic by Boster Bio
All BIRC7 Products
Product
Figures
Specificity
Applications
Price
Human Livin ELISA Kit PicoKine®
1 Citations 7 Q&As
Human
ELISA
$499
Cat # EK1348
96 wells/kit, with removable strips.
Cat # EK1348
96 wells/kit, with removable strips.
Human
Flow Cytometry, IHC, WB
$523
Cat # M02577
100 µl
Cat # M02577
100 µl
Human
Flow Cytometry, IF, WB
$523
Cat # M02577-1
100 µl
Cat # M02577-1
100 µl
BIRC7 Overview
Facts about Baculoviral IAP repeat-containing protein 7.
Baculoviral IAP repeat-containing protein 7 (BIRC7)
Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic actions and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, in addition to by its E3 ubiquitin-protein ligase activity.
As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to interrupt XIAP/BIRC4-caspase interactions.
Gene Information
| Human | |
|---|---|
| Gene Name: | BIRC7 |
| Uniprot: | Q96CA5 |
| Entrez: | 79444 |
Family
| Belongs to: |
|---|
| IAP family |
Alternative Names
baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing 7; BIRC7; KIAP; KIAPRING finger protein 50; Kidney inhibitor of apoptosis protein; livin inhibitor-of-apoptosis; Livin; Melanoma inhibitor of apoptosis protein; ML-IAP; MLIAPlivin inhibitor of apoptosis; ML-IAPmliap; RNF50LIVINbaculoviral IAP repeat-containing protein 7
Molecular Weight
Mass (kDA):
32.798 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.33 |
| Sequence: | 20; NC_000020.11 (63235905..63240495) |
Tissue Specificity
Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
Subcellular Localizations
Nucleus. Cytoplasm. Golgi apparatus. Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Diseases
- Malignant Neoplasms
- Neoplasms
- Melanoma
- Carcinoma
- Neoplasm Metastasis
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Malignant Neoplasm Of Urinary Bladder
- Bladder Neoplasm
- Leukemia
- Adenocarcinoma
Interacting Proteins
- AES
- BIRC2
- CASP9
- DDX6
- DIABLO
- FAM124B
- HTRA2
- PHF1
- POLR1C
Pathways
- Cell Proliferation
- Rna Interference
- Cell Cycle
- Cell Death
- Drug Resistance
- Cell Growth
- Pathogenesis
- Reverse Transcription
- Gene Silencing
- Localization
- Immune Response
- Cell Cycle Arrest
- Sensitization
PTMs
- Cleavage
Research Areas
- Apoptosis
- Zinc Finger
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BIRC7
bosterbio.com/bosterbio-gene-info-cards/BIRC7
References
PMID: 11162435 by Lin J.-H., et al. KIAP, a novel member of the inhibitor of apoptosis protein family.
PMID: 11322947 by Ashhab Y., et al. Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern.
2 Publications of Boster BIRC7 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s11010-017-3043-8, LncRNA CCAT1 inhibits cell apoptosis of renal cell carcinoma through up-regulati...
- PubMed ID: 24223461, Expression and Clinical Significance of Livin Protein in Hepatocellular Carcinom...
*More publications can be found for each product on its corresponding product page