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Product Info Summary
| SKU: | A04957 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-LEMD3 Antibody
SKU/Catalog Number
A04957
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LEMD3 Antibody (Catalog # A04957). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
LEMD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-LEMD3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04957)
Host
Rabbit
Contents
LEMD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
LEMD3 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LEMD3. The immunogen is located within the last 50 amino acids of LEMD3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of LEMD3 are known to exist; this antibody will detect all isoforms. LEMD3 antibody is predicted to not cross-react with LEMD1 and LEMD2
Reactive Species
A04957 is reactive to LEMD3 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
99997 MW
Background of LEMD3
LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04957 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
LEMD3 antibody can be used for detection of LEMD3 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of LEMD3 in human colon tissue lysate with LEMD3 antibody at 1 μg/mL.
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Immunohistochemistry of LEMD3 in human colon tissue with LEMD3 antibody at 2.5 μg/mL.
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Immunofluorescence of LEMD3 in human colon tissue with LEMD3 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For LEMD3 (Source: Uniprot.org, NCBI)
Gene Name
LEMD3
Full Name
Inner nuclear membrane protein Man1
Weight
99997 MW
Alternative Names
MAN1, MAN1, Inner nuclear membrane protein Man1, LEM domain-containing protein 3 LEMD3 MAN1 LEM domain containing 3 inner nuclear membrane protein Man1|LEM domain-containing protein 3|LEMD3/MKX fusion|MAN 1|integral inner nuclear membrane protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LEMD3, check out the LEMD3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LEMD3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LEMD3 Antibody (A04957)
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