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LEMD3 Antibodies

AND LEMD3 ELISA kits, LEMD3 Proteins

Many biological assays use antibodies to detect LEMD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LEMD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LEMD3 antibodies...

We validate the specificity of these antibodies to LEMD3 by testing them on tissues known to express LEMD3 positively and negatively. Browse below to find the LEMD3 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LEMD3 Infographic by Boster Bio

LEMD3 protein infographic

All LEMD3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-LEMD3 Antibody

Human, Mouse

ELISA, IF, IHC-P, WB

$449
Cat # A04957
0.1 mg

MAN1 (LEMD3) (NM_001167614) Human Recombinant Protein

$813
Cat # PROTQ9Y2U8
20 µg

Anti-MAN1 (LEMD3) Mouse Monoclonal Antibody [Clone ID: OTI3H1]

Dog, Human, Monkey, Mouse, Rat

Flow Cytometry, IP, IF, WB

$523
Cat # M04957
100 µl

MAN1 (LEMD3) (NM_014319) Human Over-expression Lysate

Human

$960
Cat # LS023592
100 µg

Anti-LEMD3 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A04957-1
100 µg/vial

LEMD3 Overview

Facts about Inner nuclear membrane protein Man1.

LEMD3 3D structure

LEMD3 3D structure. Source: alphafold

Inner nuclear membrane protein Man1 (LEMD3)

Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.

.

Gene Information

Human
Gene Name:	LEMD3
Uniprot:	Q9Y2U8
Entrez:	23592

Gene Information

Family

Belongs to:

No superfamily

Family

Alternative Names

inner nuclear membrane protein Man1; integral inner nuclear membrane protein; LEM domain containing 3; MAN1LEM domain-containing protein 3

Molecular Weight

Mass (kDA):
99.997 kDA

Molecular Weight

Genomic Context


Human

Location:	12q14.3
Sequence:	12; NC_000012.12 (65169583..65248355)

Tissue Specificity

Heart, brain, placenta, lung, liver and skeletal muscle.

Subcellular Localizations

Nucleus inner membrane; Multi-pass membrane protein.

Subcellular Localization

Diseases

Osteopoikilosis (disorder)
Dermatofibrosis Lenticularis Disseminata
Melorheostosis
Dwarfism
Melanocytic Nevus
Cytogenetic Abnormality
Failure To Thrive
Germline Mutation Abnormality
Haploinsufficiency
Russell-silver Syndrome
Developmental Delay (disorder)
Learning Disabilities

Connective Tissue Diseases
Skin Diseases, Genetic
Speech Delay
Bone Diseases
Growth Disorders
Learning Disorders

Disease

Interacting Proteins

SMAD1

Interacting Proteins

Pathways

Cell Proliferation

Pathways

PTMs

Phosphorylation

Methylation

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LEMD3

References

PMID: 10671519 by Lin F., et al. MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin.

PMID: 15489854 by Hellemans J., et al. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.