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Product Info Summary
| SKU: | M01654 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | Flow Cytometry, IP, WB |
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Product info
Product Name
Anti-LAT Purified Monoclonal Antibody
SKU/Catalog Number
M01654
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-LAT Purified Monoclonal Antibody (Catalog# M01654). Tested in WB, IP, Flow Cytometry application(s). This antibody reacts with Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-LAT Purified Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01654)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
LAT-01
Isotype
Mouse IgG1
Immunogen
Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT. The antibody LAT-01 reacts with an intracellular epitope of LAT, a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
M01654 is reactive to LAT in Human
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
27930 MW
Background of Lat
LAT (linker for activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M01654 is guaranteed for Flow Cytometry, IP, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunoprecipitation: Tyrosine-phosphorylated form of LAT is not optimally recognized.
Flow cytometry: 1-4 µg/ml, intracellular staining. Tyrosine-phosphorylated form of LAT is not optimally recognized.
Western blotting: 1-2 μg/ml.
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For LAT (Source: Uniprot.org, NCBI)
Gene Name
LAT
Full Name
Linker for activation of T-cells family member 1
Weight
27930 MW
Alternative Names
IMD52 Lat|p36-38, pp36|linker for activation of T cells|linker for activation of T-cells family member 1|36 kDa phospho-tyrosine adapter protein|linker protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LAT, check out the LAT Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LAT: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LAT Purified Monoclonal Antibody (M01654)
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No publications found for M01654
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