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Product Info Summary
| SKU: | A10759 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Kremen protein 1 KREMEN1 Antibody
SKU/Catalog Number
A10759
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Kremen protein 1 KREMEN1 Antibody (Catalog # A10759). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
KREMEN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Kremen protein 1 KREMEN1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10759)
Host
Rabbit
Contents
KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1. The immunogen is located within the last 50 amino acids of KREMEN1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Three isoforms of KREMEN1 exists as a result of alternative splicing event.
Reactive Species
A10759 is reactive to KREMEN1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
51744 MW
Background of Kremen-1
Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A10759 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of KREMEN1 in rat small intestine tissue lysate with KREMEN1 antibody at (A) 0.125 and (B) 0.25 μg/mL
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Immunohistochemistry of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 5 μg/ml.
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Immunofluorescence of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For KREMEN1 (Source: Uniprot.org, NCBI)
Gene Name
KREMEN1
Full Name
Kremen protein 1
Weight
51744 MW
Alternative Names
KRM1, KREMEN, KRM1, Kremen protein 1, Dickkopf receptor KREMEN1 ECTD13, KREMEN, KRM1 kringle containing transmembrane protein 1 kremen protein 1|dickkopf receptor|kringle domain-containing transmembrane protein 1|kringle-coding gene marking the eye and the nose|kringle-containing protein marking the eye and the nose
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KREMEN1, check out the KREMEN1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KREMEN1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Kremen protein 1 KREMEN1 Antibody (A10759)
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