Kremen protein 1 Antibodies

AND KREMEN1 ELISA kits, Kremen protein 1 Proteins

Many biological assays use antibodies to detect Kremen protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Kremen protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Kremen protein 1 antibodies...

We validate the specificity of these antibodies to Kremen protein 1 by testing them on tissues known to express KREMEN1 positively and negatively. Browse below to find the KREMEN1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KREMEN1 Infographic by Boster Bio

All KREMEN1 Products

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Figures

Specificity

Applications

Price

Mouse Kremen-1 ELISA Kit PicoKine®

8 Q&As

Mouse

ELISA

$750
Cat # EK1538
96 wells/kit, with removable strips.

Anti-Kremen protein 1 KREMEN1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A10759
0.1 mg

KREMEN1 (NM_001039571) Human Recombinant Protein

$813
Cat # PROTQ96MU8
20 µg

KREMEN1 Overview

Facts about Kremen protein 1.

KREMEN1 3D structure. Source: alphafold

Kremen protein 1 (KREMEN1)

Receptor for Dickkopf proteins.
Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by boosting the endocytosis of Wnt receptors LRP5 and LRP6.

In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can activate apoptosis in a Wnt-independent fashion and this apoptotic activity is inhibited upon binding of the ligand DKK1.

Gene Information

Human
Gene Name:	KREMEN1
Uniprot:	Q96MU8
Entrez:	83999

Family

Belongs to:

No superfamily

Alternative Names

EC 3.4.21; FLJ31863; KREMEM1; kremen protein 1; KREMEN; Kremen1; Kremen-1; kringle containing transmembrane protein 1; kringle containing transmembrane protein; Kringle domain-containing transmembrane protein 1; kringle-coding gene marking the eye and the nose; Kringle-containing protein marking the eye and the nose; KRM1; KRM1Dickkopf receptor

Molecular Weight

Mass (kDA):
51.744 kDA

Genomic Context


Human

Location:	22q12.1
Sequence:	22; NC_000022.11 (29073035..29168333)

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Limb Deformities, Congenital
Tissue Adhesions
Neoplasms
Ophthalmoplegia
Anterior Segment Ischemia
Microcephaly
Malnutrition
Stenosis
Ischemia
Limb Defect
Nerve Degeneration
Schizophrenia

Multiple Myeloma
Heart Diseases
Disorder Of Eye
Malignant Neoplasms
Nervousness
Leukemia
Osteoporosis

Pathways

Endocytosis
Limb Development
Embryo Implantation
Pathogenesis
Transport
Clathrin-mediated Endocytosis
Cell Adhesion
Hair Follicle Development
Gastrulation
Cell Proliferation
Osteoblast Differentiation
Somitogenesis
Lung Development

Glycosylation
Larval Development
Localization
Protein Glycosylation
Decidualization
Cell Differentiation
Cell Growth

PTMs

Glycosylation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KREMEN1

References

PMID: 17804805 by Binnerts M.E., et al. R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6.

PMID: 27049303 by Issa Y.A., et al. Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families.