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Product Info Summary
| SKU: | M01021-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Mouse |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-IRAK IRAK1 Monoclonal Antibody [8F1A7]
SKU/Catalog Number
M01021-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IRAK IRAK1 Monoclonal Antibody [8F1A7] (Catalog # M01021-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse.
Storage & Handling
IRAK monoclonal antibody can be stored at -20°C, stable for one year.
Cite This Product
Anti-IRAK IRAK1 Monoclonal Antibody [8F1A7] (Boster Biological Technology, Pleasanton CA, USA, Catalog # M01021-1)
Host
Mouse
Contents
IRAK Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Monoclonal
Clone Number
Clone: 8F1A7
Isotype
IgG1
Immunogen
Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ORAI1 antibody is predicted to have no cross reactivity to other members in the ORAI family.
Reactive Species
M01021-1 is reactive to IRAK1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
76537 MW
Background of IRAK1
Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M01021-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IRAK antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IRAK in mouse liver lysate with IRAK antibody at (A) 1 and (B) 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For IRAK1 (Source: Uniprot.org, NCBI)
Gene Name
IRAK1
Full Name
Interleukin-1 receptor-associated kinase 1
Weight
76537 MW
Superfamily
protein kinase superfamily
Alternative Names
IRAK, pelle IRAK1 IRAK, pelle interleukin 1 receptor associated kinase 1 interleukin-1 receptor-associated kinase 1|IRAK-1|Pelle homolog
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IRAK1, check out the IRAK1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IRAK1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IRAK IRAK1 Monoclonal Antibody [8F1A7] (M01021-1)
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