Interleukin-1 receptor-associated kinase 1 (IRAK1)

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Is rapidly recruited by MYD88 into the receptor- signaling complex upon TLR activation.

Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1.