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Product Info Summary
| SKU: | A03455-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-IL-36RN Antibody
View all IL-36Ra/IL-1F5 Antibodies
SKU/Catalog Number
A03455-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IL-36RN Antibody (Catalog # A03455-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
IL-36RN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-IL-36RN Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03455-1)
Host
Rabbit
Contents
IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IL-36RN antibody was raised against a 19 amino acid peptide near the carboxy terminus of human IL-36RN. The immunogen is located within the last 50 amino acids of IL-36RN.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist
Reactive Species
A03455-1 is reactive to IL36RN in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
16962 MW
Background of IL-36Ra/IL-1F5
IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1). IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2). The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3). Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03455-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IL-36RN antibody can be used for detection of IL-36RN by Western blot at 1 μg/ml.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IL-36RN in human spleen tissue lysate with IL-36RN antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of IL-36RN in rat small intestine tissue with IL-36RN antibody at 5 μg/mL.
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Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For IL36RN (Source: Uniprot.org, NCBI)
Gene Name
IL36RN
Full Name
Interleukin-36 receptor antagonist protein
Weight
16962 MW
Superfamily
IL-1 family
Alternative Names
FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1(DELTA), UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3 IL36RN FIL1, FIL1(DELTA), FIL1D, IL-36Ra, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, PSORS14 interleukin 36 receptor antagonist interleukin-36 receptor antagonist protein|IL-1 related protein 3|IL-1F5 (IL-1HY1, FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta)|IL-1ra homolog 1|IL1F5 (Canonical product IL-1F5a)|interleukin 1 family, member 5 (delta)|interleukin-1 HY1|interleukin-1 receptor antagonist homolog 1|interleukin-1-like protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IL36RN, check out the IL36RN Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IL36RN: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IL-36RN Antibody (A03455-1)
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