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- Table of Contents
Facts about Interleukin-36 receptor antagonist protein.
Proposed to play a part in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
Human | |
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Gene Name: | IL36RN |
Uniprot: | Q9UBH0 |
Entrez: | 26525 |
Belongs to: |
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IL-1 family |
FIL1 delta; FIL1; FIL1-delta, IL-1RP3, IL-1L1, IL-1-delta); FIL1DIL-1 delta; IL1F5 (Canonical product IL-1F5a); IL1F5; IL-1HY1; IL-1L1; IL-1RP3; IL36Ra; IL-36Ra; IL36RN; interleukin 1 family, member 5 (delta); interleukin 1, delta; Interleukin 36 Receptor Antagonist; interleukin-1 family member 5; Interleukin-1 HY1; Interleukin-1 receptor antagonist homolog 1; Interleukin-1-like protein 1; Interleukin-36 Receptor Antagonist
Mass (kDA):
16.962 kDA
Human | |
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Location: | 2q14.1 |
Sequence: | 2; NC_000002.12 (113058638..113064744) |
Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
Secreted.
PMID: 10625660 by Smith D.E., et al. Four new members expand the IL-1 superfamily.
PMID: 10512743 by Mulero J.J., et al. IL1HY1: a novel interleukin-1 receptor antagonist gene.