Interleukin-36 receptor antagonist protein (IL36RN)

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of this IL-36 signaling system that's considered to be present in epithelial barriers and to get involved in local inflammatory response; like the IL-1 system with which it shares the coreceptor.

Proposed to play a part in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.