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Product Info Summary
| SKU: | A01160-2 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-IL-11 Antibody
SKU/Catalog Number
A01160-2
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IL-11 Antibody (Catalog # A01160-2). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
IL-11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-IL-11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01160-2)
Host
Rabbit
Contents
IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11. The immunogen is located within amino acids 40 - 90 of IL-11.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.
Reactive Species
A01160-2 is reactive to IL-11 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
21429 MW
Background of IL-11
Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01160-2 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
IL-11 antibody can be used for the detection of IL-11 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry at 10 μg/ml.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IL-11 in Hela Cell lysate with IL-11 antibody at 1 μg/ml.
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Immunocytochemistry of IL-11 in HeLa cells with IL-11 antibody at 10 μg/ml.
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Immunofluorescence of IL-11 in HeLa cells with IL-11 antibody at 20 μg/ml.
Red: IL-11 Antibody (A01160-2)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For IL-11 (Source: Uniprot.org, NCBI)
Gene Name
IL-11
Full Name
Interleukin-11
Weight
21429 MW
Superfamily
IL-6 superfamily
Alternative Names
Interleukin-11, Adipogenesis inhibitory factor, AGIF IL11 AGIF, IL-11 interleukin 11 interleukin-11|adipogenesis inhibitory factor|oprelvekin
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IL-11, check out the IL-11 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IL-11: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IL-11 Antibody (A01160-2)
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