Key=store_id
Key=entity_id, value=1606
Key=attribute_set_id, value=4
Key=type_id, value=simple
Key=sku, value=PA2036-1
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2014-04-09 15:19:18
Key=updated_at, value=2024-10-19 05:03:13
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-IKK beta/IKBKB Antibody Picoband®
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Key=is_recurring, value=No
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Key=featured, value=No
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Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
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Key=yoast_keyword_score, value=-1575
Key=yoast_content_score, value=60
Key=badge, value=free-antibody-validation
Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=Anti-IKK beta/IKBKB Antibody PA2036-1
Key=meta_description, value=Boster Bio Anti-IKK beta/IKBKB Antibody catalog # PA2036-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100μg/vial in Lyophilized form antibody.
Key=image, value=/p/a/pa2036-1-1.jpg
Key=small_image, value=/p/a/pa2036-1-1.jpg
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Key=url_key, value=anti-ikk-beta-antibody-pa2036-1-boster
Key=url_path, value=anti-ikk-beta-antibody-pa2036-1-boster
Key=options_container, value=Product Info Column
Key=image_label, value=Anti- IKBKB antibody, PA2036-1, Western blotting
All lanes: Anti IKBKB (PA2036-1) at 0.5ug/ml
Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Lane 3: PANC Whole Cell Lysate at 40ug
Lane 4:
Key=small_image_label, value=Anti- IKBKB antibody, PA2036-1, Western blotting
All lanes: Anti IKBKB (PA2036-1) at 0.5ug/ml
Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Lane 3: PANC Whole Cell Lysate at 40ug
Lane 4:
Key=thumbnail_label, value=Anti- IKBKB antibody, PA2036-1, Western blotting
All lanes: Anti IKBKB (PA2036-1) at 0.5ug/ml
Lane 1: Rat Cardiac Muscle Tissue Lysate at 50ug
Lane 2: Rat Skeletal Muscle Tissue Lysate at 50ug
Lane 3: PANC Whole Cell Lysate at 40ug
Lane 4:
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Key=gift_message_available, value=No
Key=size, value=100 μg/vial
Key=protein_name, value=Inhibitor of nuclear factor kappa-B kinase subunit beta
Key=gene_full_name, value=Inhibitor of nuclear factor kappa-B kinase subunit beta
Key=uniprot_id, value=O14920
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
Key=predicted_reactivity
Key=source_company, value=Boster PA2036-1
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=86564 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Atherosclerosis, Cardiovascular, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, NFKB Pathway, Nuclear Signaling Pathways, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, TLR Signaling, Vascular Inflammation
Key=clonality, value=Polyclonal
Key=swatch_image, value=/antibody/ek0949-2-ELISA-human-kallikrein-14-picokine-elisa-kit.jpg
Key=rating_value, value=98.5
Key=review_count, value=10
Key=phospho_site
Key=mp_exclude_sitemap, value=Yes
Key=yoast_focus_keyword, value=CD68 antibody
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Key=yoast_twitter_image, value=/p/a/pa1787-2-hexa-primary-antibodies-wb-testing-1_1.jpg
Key=cj_related_products, value=Immunology:PA2223|EK1421|A00360-1|A00360-2^Innate Immunity:PA1943-1|A00144-Dyl550
Key=description, value=Boster Bio Anti-IKK beta/IKBKB Antibody catalog # PA2036-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-IKK beta/IKBKB Antibody catalog # PA2036-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-IKK beta/IKBKB Antibody
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Key=background, value=IKBKB (Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Kinase of, Beta), also known as IKKB or NFKBIKB , is a protein that in humans is encoded by the IKBKB gene. Shindo et al. (1998) mapped the IKBKB gene to chromosome 8p12-p11 by FISH. Mercurio et al. (1997) found that mutations in IKK2 had a more pronounced effect upon NFKB activation than did comparable mutations in IKK1. Yin et al. (1998) tested the activity of various antiinflammatory agents on the IKK complex. They demonstrated that aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo by binding to IKK-beta to reduce ATP binding.
Key=gene_name, value=IKBKB
Key=synonyms, value=Inhibitor of nuclear factor kappa-B kinase subunit beta;I-kappa-B-kinase beta;IKK-B;IKK-beta;IkBKB;2.7.11.10;I-kappa-B kinase 2;IKK2;Nuclear factor NF-kappa-B inhibitor kinase beta;NFKBIKB;IKBKB;IKKB;
Key=application_details, value=Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Key=subcellular_localization, value= Cytoplasm. Nucleus. Membrane raft. Colocalized with DPP4 in membrane rafts.
Key=sequence_similarities, value=Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Key=tissue_specificity, value= Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Key=application_notes, value=WB: The detection limit for IKBKB is approximately 0.5ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 130152|sc 135948|sc 161731|sc 161733|sc 21660|sc 21660 R|sc 21661|sc 21661 R|sc 23470 R|sc 271782|sc 34673|sc 34674|sc 56918|sc 7218|sc 7329|sc 7329 R|sc 7330|sc 7607|sc 8014
Key=immunogen, value=A synthetic peptide corresponding to a sequence at the C-terminus of human IKK beta, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=87 kDa
Key=custom_attribute_2, value=WB: Rat Cardiac Muscle Tissue, Rat Skeletal Muscle Tissue, PANC Whole Cell, MCF-7Whole Cell, HEPG2 Whole Cell, COLO320 Cell
Key=protein_function, value= Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. .
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