IKBKB Antibodies

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli like inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the traditional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on two critical serine residues.

These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. Subsequently, free NF-kappa-B is translocated to the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.

Gene Information

Human
Gene Name:	IKBKB
Uniprot:	O14920
Entrez:	3551

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.10; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK beta; IKK2; IKK2FLJ38368; IKK-B; IKK-betaFLJ36218; IKKBFLJ40509; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; NFKBIKBFLJ33771; Nuclear factor NF-kappa-B inhibitor kinase beta

Molecular Weight

Mass (kDA):
86.564 kDA

Genomic Context

Human
Location:	8p11.21
Sequence:	8; NC_000008.11 (42270727..42332653)

Tissue Specificity

Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.

Subcellular Localizations

Cytoplasm. Nucleus. Membrane raft. Colocalized with DPP4 in membrane rafts.

Diseases

• Inflammation
• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Cell Transformation, Neoplastic
• Leukemia
• Tissue Adhesions
• Inflammatory Response
• Lymphoma
• Diabetes Mellitus
• Arthritis
• Immunologic Deficiency Syndromes
• Mammary Neoplasms

• Insulin Resistance
• Malignant Paraganglionic Neoplasm
• Virus Diseases
• Rheumatoid Arthritis
• Infective Disorder
• Malignant Neoplasm Of Breast
• Neoplasm Metastasis

Interacting Proteins

• AURKA
• CDC37
• CHUK
• CREBBP
• HSP90AB1

• IKBKG
• KEAP1
• MAP3K14
• NCOA3
• NFKB1

• NFKBIA
• PPP2CA
• RELA
• RPS3
• STAP2

• TNIK
• TP53
• TSC1
• Zc3h12a

Pathways

• Cell Death
• Pathogenesis
• Immune Response
• Cell Proliferation
• Localization
• Inflammatory Response
• Secretion
• Cell Cycle
• Cell Activation
• Cell Growth
• Proteolysis
• Cytokine Production
• Angiogenesis

• Induction Of Apoptosis
• Innate Immune Response
• Cell Adhesion
• T Cell Activation
• Sensitization
• Rna Interference
• Oncogenesis

PTMs

• Phosphorylation
• Ubiquitination
• Cleavage
• Reduction
• Acetylation
• Dephosphorylation
• Oxidation

• Nitrosylation
• Biotinylation
• Sumoylation
• Hydroxylation
• Acylation
• Farnesylation
• Methylation

• Geranylgeranylation

Research Areas

• Cancer
• Immunology
• Innate Immunity
• mTOR Pathway
• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IKBKB

Boster Bio - Best Uses Of The IKBKB Marker

If you're interested in learning more about Boster Bio and the IKBKB marker, then read this article. This article will give you information about this important marker. The Boster Bio Antiphospho-IK beta (Y199) is highly regarded, exclusive protein. It is used to test the effects of species and applications. It can also be utilized by scientists from all over the world. Here are the most effective uses of the IKBKB.

Boster Bio Anti-Phospho-IK beta (Y199)

Boster Bio Anti-Phospho-Phospho-IK beta (R291) is part of the Picoband(tm) antibody collection. It has been tested for use in Flow Cytometry and immunohistochemistry, including ICC and IHC-P. This antibody reacts to Humans mice, rats, and. It is made up of 5 mg bovine serum albumin (BSA).