Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli like inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the traditional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on two critical serine residues.

These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. Subsequently, free NF-kappa-B is translocated to the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis.