Anti-Human NFAT2 DyLight® 488 conjugated NFATC1 Antibody

Product Name

Anti-Human NFAT2 DyLight® 488 conjugated NFATC1 Antibody

View all NFATC1/NFAT2 Antibodies

SKU/Catalog Number

A00340-Dyl488

Size

100 μg/vial

Form

Liquid

Description

Boster Bio Anti-Human NFAT2 DyLight® 488 conjugated NFATC1 Antibody catalog # A00340-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

Storage & Handling

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Cite This Product

Anti-Human NFAT2 DyLight® 488 conjugated NFATC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00340-Dyl488)

Host

Rabbit

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

E. coli-derived human NFAT2 recombinant protein (Position: Q589-K652).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

A00340-Dyl488 is reactive to NFATC1 in Human

Reconstitution

Observed Molecular Weight

39 kDa

Calculated molecular weight

101.243kDa

Background of NFATC1/NFAT2

NFATC1 (Nuclear factor of activated T-cells, cytoplasmic 1), also known as NFATC or NFAT2, is a protein that in humans is encoded by the NFATC1 gene. And it is also a component of the nuclear factor of activated T cells DNA-binding transcription complex. The NFATC1 gene is mapped on 18q23. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. NFATC1 was not detected in brain, liver, or kidney. NFATC1 is an inducible nuclear component which functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. The solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the 12-bp oligonucleotide duplex containing the ARRE2 DNA site from the IL2 promoter. Nfatc1 was expressed exclusively in mouse hair follicle stem cells, and using gain- and loss-of-function approaches, and Nfatc1 inhibited stem cell activation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A00340-Dyl488 is guaranteed for Flow Cytometry Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells

Validation Images & Assay Conditions

Gene/Protein Information For NFATC1 (Source: Uniprot.org, NCBI)

Alternative Names

Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc; NFATC1; NFAT2; NFATC NFATC1 NF-ATC, NF-ATc1.2, NFAT2, NFATc nuclear factor of activated T cells 1 nuclear factor of activated T-cells, cytoplasmic 1|NFAT transcription complex cytosolic component|nuclear factor of activated T-cells c|nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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