NFATC1 Antibodies

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells.

Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes in addition to lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).

Gene Information

Human
Gene Name:	NFATC1
Uniprot:	O95644
Entrez:	4772

Family

Belongs to:
No superfamily

Alternative Names

MGC138448; NFAT transcription complex cytosolic component; NFAT2; NFAT2cytoplasmic 1; NFATC; NF-ATC; NFATC1; NF-ATc1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Molecular Weight

Mass (kDA):
101.243 kDA

Genomic Context

Human
Location:	18q23
Sequence:	18; NC_000018.10 (79395930..79529323)

Tissue Specificity

Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity).

Diseases

• Osteoporosis
• Arthritis
• Osteopenia
• Rheumatoid Arthritis
• Bone Diseases
• Inflammation
• Neoplasms
• Malignant Neoplasms
• Hypertrophy
• Lymphoma
• Periodontitis
• Neoplasm Metastasis

• Fracture
• Albers-schonberg Disease
• Diabetes Mellitus
• Autoimmune Reaction
• Heart Diseases
• Atherosclerosis
• Carcinoma

Interacting Proteins

• ATF1
• ATF2
• ATF3
• CREB1
• HOXC13

• JUN
• OGT

Pathways

• Osteoclast Differentiation
• Bone Resorption
• Localization
• Cell Proliferation
• Cell Activation
• Pathogenesis
• Osteoblast Differentiation
• Cell Differentiation
• T Cell Activation
• Secretion
• Bone Remodeling
• Cell Growth
• Nuclear Export

• Rna Interference
• Nuclear Import
• Cell Migration
• Osteoclast Development
• Immune Response
• Cytokine Production
• Cell Death

PTMs

• Phosphorylation
• Dephosphorylation
• Acetylation
• Ubiquitination
• Cleavage
• Methylation

• Sumoylation
• Demethylation
• Myristoylation
• Nitrosylation
• Hydroxylation
• Biotinylation

• Reduction

Research Areas

• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFATC1

Boster Bio Anti-NFATC1 Antibody Picoband and Broad Spectrum Protease Inhibitor Cocktail

If you're interested in Boster Bio Anti-NFATC1 Antibody Picoband as well as the Broad Spectrum Protease Inhibitor Cocktail You're in the right place. This article will explain the differences between these products and which one is best for your application. We'll also explain the best way to use these products. Here are a few of the most effective uses for these items.

Boster Bio's AntiNFAT1/NFATC2 Antibody Pioband(tm).

The boster bio Anti-NFAT1/NFATC2 antibody is part of the Picoband(tm) antibody collection and is able to react with Rat and Mouse. Multiple platforms have validated this antibody with positive and negative samples. This ensures high specificity and a high affinity. The company provides product credits to the first reviewers and awards all scientists around the world.

Boster Bio's Broad Spectrum Protease Inhibitor Cocktail (tm)

Broad Spectrum Protease Inhibitor Cocktail can be called a BSPI. It is a mixture of a variety of protease inhibitors in liquid form. It protects native cellular proteins by blocking a variety of proteases. It is an alternative to traditional tablets and has enhanced solubility. BSPI 100X is suggested for use with Western blots.

BSPI contains peptide based membrane combination inhibitors that inhibit spike proteins of HCoV-2E HR1 and HR2 domains. These peptides inactivate SARS-CoV in vitro and in vivo. In a recent research, the peptides prevented SARS-CoV infection using a synthesis of the spike protein of the virus (B.1.617).

Boster Bio's Anti NFATc2IP from Bio

Boster Bio's Anti-NFATTC2-interacting protein NFATc2IP Marker (Catalog Number: A11329) is a rabbit polyclonal antibody that reacts with the Human NFATc2IP protein. It can be stored at -20degC for up to a year when stored in PBS that contains 50% Glycerol. You can purchase blocking proteins with a specific length.