NFATC1 Antibodies

AND NFATC1 ELISA kits, NFATC1 Proteins

Many biological assays use antibodies to detect NFATC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFATC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFATC1 antibodies...

We validate the specificity of these antibodies to NFATC1 by testing them on tissues known to express NFATC1 positively and negatively. Browse below to find the NFATC1 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NFATC1 Infographic by Boster Bio

All NFATC1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-NFAT2/NFATC1 Antibody Picoband®

4 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, ICC, WB

$370
Cat # A00340-1
100 μg/vial

Anti-NFAT2 NFATC1 Rabbit Monoclonal Antibody

4 Q&As

Human

Flow Cytometry, IF, ICC, WB

$370
Cat # M00340
100 μl

Anti-Human NFAT2 DyLight® 488 conjugated NFATC1 Antibody

14 Q&As

Human

Flow Cytometry

$515
Cat # A00340-Dyl488
100 μg/vial

Anti-Human NFAT2 DyLight® 550 conjugated NFATC1 Antibody

3 Q&As

Human

Flow Cytometry

$515
Cat # A00340-Dyl550
100 μg/vial

Anti-NFAT2/NFATC1 Antibody Picoband®

1 Citations 4 Q&As

Human, Mouse, Rat

ELISA, WB

$370
Cat # A00340-2
100 μg/vial

Anti-Phospho-NFATc1 (S294) Antibody

Human, Mouse

ELISA, IHC-P

$380
Cat # A00340S294
100ul

NFAT2 (NFATC1) (NM_172390) Human Over-expression Lysate

Human

$628
Cat # LS004772
100 µg

NFATC1 Overview

Facts about Nuclear factor of activated T-cells, cytoplasmic 1.

NFATC1 3D structure. Source: alphafold

Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells.

Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes in addition to lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).

Gene Information

Human
Gene Name:	NFATC1
Uniprot:	O95644
Entrez:	4772

Family

Belongs to:

No superfamily

Alternative Names

MGC138448; NFAT transcription complex cytosolic component; NFAT2; NFAT2cytoplasmic 1; NFATC; NF-ATC; NFATC1; NF-ATc1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Molecular Weight

Mass (kDA):
101.243 kDA

Genomic Context


Human

Location:	18q23
Sequence:	18; NC_000018.10 (79395930..79529323)

Tissue Specificity

Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity).