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Product Info Summary
| SKU: | A00192 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-FMR1 Antibody
SKU/Catalog Number
A00192
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FMR1 Antibody (Catalog # A00192). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
FMR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-FMR1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00192)
Host
Rabbit
Contents
FMR1 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1. The immunogen is located within the last 50 amino acids of FMR1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
Reactive Species
A00192 is reactive to FMR1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
71174 MW
Background of FMRP
Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00192 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of FMR1 in rat brain tissue lysate with FMR1 antibody at 1 μg/ml.
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Immunohistochemistry of FMR1 in human brain tissue with FMR1 antibody at 2.5 μg/mL.
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Immunofluorescence of FMR1 in human brain tissue with FMR1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FMR1 (Source: Uniprot.org, NCBI)
Gene Name
FMR1
Full Name
Synaptic functional regulator FMR1
Weight
71174 MW
Superfamily
FMR1 family
Alternative Names
Fragile X mental retardation protein 1, FMRP FMR1 FMRP, FRAXA, POF, POF1 FMRP translational regulator 1 synaptic functional regulator FMR1|fragile X mental retardation 1|fragile X mental retardation protein 1|truncated FMRP
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FMR1, check out the FMR1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FMR1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FMR1 Antibody (A00192)
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