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FMR1 Antibodies
AND FMR1 ELISA kits, FMR1 Proteins
Many biological assays use antibodies to detect FMR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FMR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FMR1 antibodies...
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FMR1 Infographic by Boster Bio
All FMR1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9703
100 μg/vial
Cat # PB9703
100 μg/vial
Chicken, Human, Mouse, Rat
IHC, WB
$481
Cat # P00192
100 µl
Cat # P00192
100 µl
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00192-1
100 µl
Cat # M00192-1
100 µl
FMR1 Overview
Facts about Synaptic functional regulator FMR1.
Synaptic functional regulator FMR1 (FMR1)
Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs (PubMed:16631377, PubMed:18653529, PubMed:19166269, PubMed:23235829, PubMed:25464849). Plays a role in the alternative splicing of its own mRNA (PubMed:18653529).
Plays a role in mRNA nuclear export (By similarity). Together with export variable NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | FMR1 |
| Uniprot: | Q06787 |
| Entrez: | 2332 |
Family
| Belongs to: |
|---|
| FMR1 family |
Alternative Names
FMRPFRAXAPOF; fragile X mental retardation 1 protein; fragile X mental retardation 1; MGC87458; POF1; premature ovarian failure 1; Protein FMR-1
Molecular Weight
Mass (kDA):
71.174 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq27.3 |
| Sequence: | X; NC_000023.11 (147911919..147951127) |
Tissue Specificity
Expressed in the brain, cerebellum and testis (PubMed:8401578). Also expressed in epithelial tissues (PubMed:8401578). Expressed in mature oligodendrocytes (OLGs) (PubMed:23891804). Expressed in fibroblast (PubMed:24204304). Expressed in neurons, Purkinje cells and spermatogonias (at protein level) (PubMed:8401578). Expressed in brain, testis and placenta (PubMed:8504300). Expressed in neurons and lymphocytes (PubMed:8504300).
Subcellular Localizations
Nucleus. Nucleus, nucleolus. Chromosome, centromere. Chromosome. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, synaptosome. Cell projection, growth cone. Cell projection, filopodium tip. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. Cell membrane. Cytoplasm, Stress granule. Colocalizes with H2AX/H2A.x in pericentrom
Diseases
- Fragile X Syndrome
- Trinucleotide Repeat Expansion
- Autistic Disorder
- Ataxia
- Premature Menopause
- Turner Syndrome
- Neurodegenerative Disorders
- Fraxa Syndrome
- Ovarian Failure, Premature
- Anxiety Disorders
- Embryonic Mosaic
- Impaired Cognition
Interacting Proteins
- CYFIP1
- CYFIP2
- FSD2
- FXR2
Pathways
- Methylation
- Translation
- Localization
- Pathogenesis
- Transport
- Dna Methylation
- Cognition
- Aging
- Menopause
- Brain Development
- Gene Silencing
- Fertilization
- Mrna Transport
PTMs
- Methylation
- Phosphorylation
- Acetylation
- Demethylation
- Dephosphorylation
Research Areas
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FMR1
bosterbio.com/bosterbio-gene-info-cards/FMR1
References
PMID: 1710175 by Verkerk A.J.M.H., et al. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.
PMID: 8504300 by Verkerk A.J.M.H., et al. Alternative splicing in the fragile X gene FMR1.