Anti-EDG-6 S1PR4 Antibody

Product Name

Anti-EDG-6 S1PR4 Antibody

View all S1P4/EDG-6 Antibodies

SKU/Catalog Number

A09413-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-EDG-6 S1PR4 Antibody catalog # A09413-1. Tested in WB,IF applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-EDG-6 S1PR4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09413-1)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

Synthetic peptide, corresponding to amino acids 275-335 of Human DC-LAMP.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A09413-1 is reactive to S1PR4 in Human, Mouse, Rat

Applications

A09413-1 is guaranteed for IF, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

41623 MW

Background of S1P4/EDG-6

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Devroe E., J. Biol. Chem. 279:24444-24451(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:1000
IF: 1:50-1:200

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-EDG-6 S1PR4 Antibody A09413-1

Western blot (WB) analysis of EDG-6 polyclonal antibody at 1:500 dilution
Lane1:HEK293T cell lysate
Lane2:Mouse liver tissue lysate
Lane3:H9C2 cell lysate
Electrophoresis was performed on a SDS-PAGE gel. To determine SDS-PAGE gel concentration

Gene/Protein Information For S1PR4 (Source: Uniprot.org, NCBI)

Alternative Names

EDG6; EDG6S1P receptor Edg-6; Endothelial differentiation G-protein coupled receptor 6; endothelial differentiation, G-protein-coupled receptor 6; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor6,endothelial differentiation, G protein coupled receptor 6; S1P receptor 4; S1P4; S1P4LPC1; S1PR4; SLP4; sphingosine 1-phosphate receptor 4; Sphingosine 1-phosphate receptor Edg-6; sphingosine-1-phosphate receptor 4 S1PR4 EDG6, LPC1, S1P4, SLP4 sphingosine-1-phosphate receptor 4 sphingosine 1-phosphate receptor 4|S1P receptor 4|S1P receptor Edg-6|endothelial differentiation G-protein coupled receptor 6|endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6|sphingosine 1-phosphate receptor Edg-6

For more info on S1PR4, check out the S1PR4 Infographic

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In this infographic, you will see the following information for S1PR4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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