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Product Info Summary
| SKU: | A02588 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-DNA-binding protein SATB2 SATB2 Antibody
SKU/Catalog Number
A02588
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DNA-binding protein SATB2 SATB2 Antibody (Catalog # A02588). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SATB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DNA-binding protein SATB2 SATB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02588)
Host
Rabbit
Contents
SATB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SATB2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human SATB2. The immunogen is located within the first 50 amino acids of SATB2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.
Reactive Species
A02588 is reactive to SATB2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
82555 MW
Background of SATB2
Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02588 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SATB2 antibody can be used for detection of SATB2 by Western blot at 2 - 4 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SATB2 in mouse brain tissue lysate with SATB2 antibody at (A) 2 and (B) 4 μg/mL.
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Immunofluorescence of SATB2 in Human Brain cells with SATB2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SATB2 (Source: Uniprot.org, NCBI)
Gene Name
SATB2
Full Name
DNA-binding protein SATB2
Weight
82555 MW
Superfamily
CUT homeobox family
Alternative Names
KIAA1034, DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2 SATB2 GLSS SATB homeobox 2 DNA-binding protein SATB2|SATB family member 2|special AT-rich sequence-binding protein 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SATB2, check out the SATB2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SATB2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DNA-binding protein SATB2 SATB2 Antibody (A02588)
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