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- Table of Contents
Facts about DNA-binding protein SATB2.
Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
Human | |
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Gene Name: | SATB2 |
Uniprot: | Q9UPW6 |
Entrez: | 23314 |
Belongs to: |
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CUT homeobox family |
DNA-binding protein SATB2; FLJ32076; KIAA1034FLJ21474; MGC119474; MGC119477; SATB family member 2; SATB homeobox 2; Special AT-rich sequence-binding protein 2
Mass (kDA):
82.555 kDA
Human | |
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Location: | 2q33.1 |
Sequence: | 2; NC_000002.12 (199269500..199471266, complement) |
High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus.
Nucleus matrix.
PMID: 14701874 by Dobreva G., et al. SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression.
PMID: 12915443 by FitzPatrick D.R., et al. Identification of SATB2 as the cleft palate gene on 2q32-q33.