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Product Info Summary
| SKU: | A01736 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-DIS3 Antibody
SKU/Catalog Number
A01736
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DIS3 Antibody (Catalog # A01736). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-DIS3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01736)
Host
Rabbit
Contents
DIS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Multiple isoforms of DIS3 are known to exist.
Reactive Species
A01736 is reactive to DIS3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
109003 MW
Background of DIS3
The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01736 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DIS3 in human ovary tissue lysate with DIS3 antibody at 1 μg/mL.
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Immunohistochemistry of DIS3 in mouse testis tissue with DIS3 antibody at 2.5 μg/ml.
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Immunofluorescence of DIS3 in mouse testis tissue with DIS3 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For DIS3 (Source: Uniprot.org, NCBI)
Gene Name
DIS3
Full Name
Exosome complex exonuclease RRP44
Weight
109003 MW
Superfamily
RNR ribonuclease family
Alternative Names
RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik, RRP44, Exosome complex exonuclease RRP44, Protein DIS3 homolog DIS3 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p DIS3 homolog, exosome endoribonuclease and 3-5 exoribonuclease exosome complex exonuclease RRP44|DIS3 exosome endoribonuclease and 3-5 exoribonuclease|DIS3 mitotic control homolog|exosome component 11|mitotic control protein dis3 homolog|ribosomal RNA-processing protein 44
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DIS3, check out the DIS3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DIS3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DIS3 Antibody (A01736)
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