Anti-DIS3-like exonuclease 2 DIS3L2 Antibody

Product Name

Anti-DIS3-like exonuclease 2 DIS3L2 Antibody

View all DIS3L2 Antibodies

SKU/Catalog Number

A07738

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-DIS3-like exonuclease 2 DIS3L2 Antibody (Catalog # A07738). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

DIS3L2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-DIS3-like exonuclease 2 DIS3L2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07738)

Host

Rabbit

Contents

DIS3L2 antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2. The immunogen is located within amino acids 720 - 770 of DIS3L2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

DIS3L2 antibody is human, mouse and rat reactive. At least three isoforms of DIS3L2 are known to exist; this antibody will only detect the longest isoform. DIS3L2 is predicted to not cross-react with DIS3 or DIS3L.

Reactive Species

A07738 is reactive to DIS3L2 in Human, Mouse, Rat

Applications

A07738 is guaranteed for ELISA, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

99279 MW

Background of DIS3L2

The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

DIS3L2 antibody can be used for detection of DIS3L2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of DIS3L2 in 3T3 cell lysate with DIS3L2 antibody at 1 μg/ml.

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Immunohistochemistry of DIS3L2 in rat brain tissue with DIS3L2 antibody at 5 μg/mL.

Gene/Protein Information For DIS3L2 (Source: Uniprot.org, NCBI)

Alternative Names

DIS3 mitotic control homolog (S. cerevisiae)-like 2; DIS3-like exonuclease 2; FAM6A; member A DIS3L2 FAM6A, PRLMNS, hDIS3L2 DIS3 like 3-5 exoribonuclease 2 DIS3-like exonuclease 2|DIS3 mitotic control homolog-like 2|family with sequence similarity 6, member A

For more info on DIS3L2, check out the DIS3L2 Infographic

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In this infographic, you will see the following information for DIS3L2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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