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Product Info Summary
| SKU: | A05203 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CTHRC1 Antibody
SKU/Catalog Number
A05203
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CTHRC1 Antibody (Catalog # A05203). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CTHRC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-CTHRC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05203)
Host
Rabbit
Contents
CTHRC1 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CTHRC1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CTHRC1. The immunogen is located within the first 50 amino acids of CTHRC1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
CTHRC1 antibody is human, mouse and rat reactive. At least two isoforms of CTHRC1 are known to exist; this antibody will detect only the larger isoform.
Reactive Species
A05203 is reactive to CTHRC1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
26224 MW
Background of Cthrc1
The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration (1). CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells (2). CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer (3). Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05203 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CTHRC1 antibody can be used for detection of CTHRC1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CTHRC1 in rat small intestine tissue lysate with CTHRC1 antibody at (A) 1 and (B) 2 μg/ml.
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Immunohistochemistry of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 5 μg/mL.
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Immunofluorescence of CTHRC1 in human small intestine tissue with CTHRC1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CTHRC1 (Source: Uniprot.org, NCBI)
Gene Name
CTHRC1
Full Name
Collagen triple helix repeat-containing protein 1
Weight
26224 MW
Alternative Names
Collagen triple helix repeat-containing protein 1 Cthrc1|1110014B07Rik|collagen triple helix repeat containing 1|collagen triple helix repeat-containing protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CTHRC1, check out the CTHRC1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CTHRC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CTHRC1 Antibody (A05203)
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