Anti-COP9 Signalosome Csn6 Subunit COPS6 Antibody

Product Name

Anti-COP9 Signalosome Csn6 Subunit COPS6 Antibody

View all COPS6 Antibodies

SKU/Catalog Number

A08543

Size

25μl/vial

Form

Liquid

Description

Boster Bio Anti-COP9 Signalosome Csn6 Subunit COPS6 Antibody catalog # A08543. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-COP9 Signalosome Csn6 Subunit COPS6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08543)

Host

Rabbit

Contents

Each vial contains 10mM sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthetic peptide corresponding to aa 283-297 of human COP9 signalosome (Csn6 subunit).

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

A08543 is reactive to COPS6 in Human

Applications

A08543 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

36163 MW

Background of COPS6

Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. PARC is a cullin family member that functions as a cytoplasmic anchor protein in p53-associated protein complexes. PARC regulates the subcellular localization of p53 and subsequent function. PARC forms a complex with p53 in the cytoplasm of unstressed cells and interacts with UBCH7 and UBCH8. PARC shows a cytoplasmic localization and is ubiquitously expressed in all tissues with highest expression in testis brain and kidney.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:1000, Human

Validation Images & Assay Conditions

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Western blot analysis of COP9 Signalosome Csn6 Subunit expression in Luminograph of a HELA S3 cytosol preparation after SDS PAGE followed by blotting onto PVDF membrane and probing with (a) antibody and (b) antibody pre-absorbed with cognate peptide. COP9 Signalosome Csn6 Subunit at 33.5KD was detected using rabbit anti-COP9 Signalosome Csn6 Subunit partially purified immunoglobulin polyclonal antibody (Catalog # A08543) at 1: 1000. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002).

Gene/Protein Information For COPS6 (Source: Uniprot.org, NCBI)

Alternative Names

BMP2B; BMP2B1; BMP4; COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); COP9 signalosome complex subunit 6; CSN6COP9 subunit 6 (MOV34 homolog, 34 kD); H_NH0506M12.12; HVIP; JAB1-containing signalosome subunit 6; MOFC11; MOV34 homolog; MOV34 homolog, 34 kD; MOV34-34KD; SGN6; Signalosome subunit 6; Vpr-interacting protein COPS6 CSN6, MOV34-34KD COP9 signalosome subunit 6 COP9 signalosome complex subunit 6|COP9 constitutive photomorphogenic homolog subunit 6|H_NH0506M12.12|JAB1-containing signalosome subunit 6|MOV34 homolog, 34 kD|SGN6|hVIP|vpr-interacting protein

For more info on COPS6, check out the COPS6 Infographic

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In this infographic, you will see the following information for COPS6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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