Anti-CD46 (Membrane Cofactor Protein) Monoclonal Antibody

Product Name

Anti-CD46 (Membrane Cofactor Protein) Monoclonal Antibody

View all CD46 Antibodies

SKU/Catalog Number

M00377

Size

100ug/vial

Form

Liquid

Description

Boster Bio Anti-CD46 (Membrane Cofactor Protein) Monoclonal Antibody (Catalog # M00377). Tested in Functional Assay, Flow Cytometry, IF applications. This antibody reacts with Human.

Storage & Handling

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Cite This Product

Anti-CD46 (Membrane Cofactor Protein) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M00377)

Host

Mouse

Contents

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Clonality

Monoclonal

Clone Number

Clone: 122.2

Isotype

IgG1, kappa

Immunogen

Recombinant human CD46 protein

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

M00377 is reactive to CD46 in Human

Reconstitution

Reconstitute with 1ml water (15 minutes at room temperature).

Calculated molecular weight

43747 MW

Background of CD46

CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M00377 is guaranteed for Flow Cytometry, IF, Functional Assay Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Functional Studies (Order Ab without Azide)
Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Validation Images & Assay Conditions

Gene/Protein Information For CD46 (Source: Uniprot.org, NCBI)

Alternative Names

Membrane cofactor protein;TLX;Trophoblast leukocyte common antigen;CD46;CD46;MCP, MIC10; CD46 AHUS2, MCP, MIC10, TLX, TRA2.10 CD46 molecule membrane cofactor protein|CD46 , complement regulatory protein|CD46 molecule, complement regulatory protein| by TRA-2-10|complement membrane cofactor protein|measles virus receptor|membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive )|trophoblast leucocyte common |trophoblast leukocyte common |trophoblast-lymphocyte cross-reactive

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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