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Product Info Summary
| SKU: | A03599-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CALHM1 Antibody
SKU/Catalog Number
A03599-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CALHM1 Antibody (Catalog # A03599-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CALHM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CALHM1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03599-1)
Host
Rabbit
Contents
CALHM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1. The immunogen is located within amino acids 60 - 110 of CALHM1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of ATG14 are known to exist; this antibody will detect all three isoforms
Reactive Species
A03599-1 is reactive to CALHM1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
38264 MW
Background of CALHM1
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03599-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of CALHM1 in rat liver tissue with CALHM1 antibody at 5 μg/mL.
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Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CALHM1 (Source: Uniprot.org, NCBI)
Gene Name
CALHM1
Full Name
Calcium homeostasis modulator protein 1
Weight
38264 MW
Superfamily
CALHM family
Alternative Names
FAM26C, FAM26C, Calcium homeostasis modulator protein 1, Protein FAM26C CALHM1 FAM26C calcium homeostasis modulator 1 calcium homeostasis modulator protein 1|family with sequence similarity 26, member C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CALHM1, check out the CALHM1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CALHM1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CALHM1 Antibody (A03599-1)
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