CALHM1 Antibodies

AND CALHM1 ELISA kits, CALHM1 Proteins

Many biological assays use antibodies to detect CALHM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CALHM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CALHM1 antibodies...

We validate the specificity of these antibodies to CALHM1 by testing them on tissues known to express CALHM1 positively and negatively. Browse below to find the CALHM1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: CFAP299

CALHM1 Infographic by Boster Bio

All CALHM1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CALHM1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A03599-1
0.1 mg

CALHM1 Overview

Facts about Calcium homeostasis modulator protein 1.

CALHM1 3D structure. Source: alphafold

Calcium homeostasis modulator protein 1 (CALHM1)

Specifically within type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release in the cell, ATP acting as a neurotransmitter to activate afferent nerve wracking pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration.

Has poor ion selectivity and creates a wide pore (around 14 Angstroms) which mediates permeation of Ca(2+), Na(+) and K(+), in addition to permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade.

Gene Information

Human
Gene Name:	CALHM1
Uniprot:	Q8IU99
Entrez:	255022

Family

Belongs to:

CALHM family

Alternative Names

calcium homeostasis modulator 1; FAM26Ccalcium homeostasis modulator protein 1; family with sequence similarity 26, member C; MGC39514; MGC39617; Protein FAM26C

Molecular Weight

Mass (kDA):
38.264 kDA

Genomic Context


Human

Location:	10q24.33
Sequence:	10; NC_000010.11 (103453240..103458900, complement)

Tissue Specificity

Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity).