Product Info Summary
SKU: | A04951-1 |
---|---|
Size: | 100 µl |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-ATF7 Antibody
SKU/Catalog Number
A04951-1
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-ATF7 Antibody (Catalog # A04951-1). Tested in WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-ATF7 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04951-1)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human ATF7.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A04951-1 is reactive to ATF7 in Human, Mouse
Reconstitution
Observed Molecular Weight
111 kDa
Calculated molecular weight
52967 MW
Background of ATF7
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family. Isoform 4/ATF-A0acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5/ATF-4acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
Gaire M., Nucleic Acids Res. 18:3467-3473(1990).
Chatton B., Submitted (DEC-1990) to the EMBL/GenBank/DDBJ databases.
Olsen J.V., Cell 127:635-648(2006).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04951-1 is guaranteed for WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of extracts from HeLa cells and HuvEc cells, using ATF7 antibody A04951-1.
Protein Target Info & Infographic
Gene/Protein Information For ATF7 (Source: Uniprot.org, NCBI)
Gene Name
ATF7
Full Name
Cyclic AMP-dependent transcription factor ATF-7
Weight
52967 MW
Superfamily
bZIP family
Alternative Names
Cyclic AMP-dependent transcription factor ATF-7;cAMP-dependent transcription factor ATF-7;Activating transcription factor 7;Transcription factor ATF-A;ATF7;ATFA; ATF7 ATFA activating transcription factor 7 cyclic AMP-dependent transcription factor ATF-7|transcription factor ATF-A
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ATF7, check out the ATF7 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ATF7: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ATF7 Antibody (A04951-1)
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