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- Table of Contents
Facts about Cyclic AMP-dependent transcription factor ATF-7.
Activator of this NF-ELAM1/delta-A site of this E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on creation of JUN or FOS heterodimers.
Human | |
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Gene Name: | ATF7 |
Uniprot: | P17544 |
Entrez: | 11016 |
Belongs to: |
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bZIP family |
activating transcription factor 7ATFATranscription factor ATF-A; cAMP-dependent transcription factor ATF-7; cyclic AMP-dependent transcription factor ATF-7; MGC57182
Mass (kDA):
52.967 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (53507856..53626415, complement) |
Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
Nucleus. Nucleus, nucleoplasm. Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.; [Isoform 5]: Cytoplasm.
PMID: 1694576 by Gaire M., et al. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells.
PMID: 8288576 by Pescini R., et al. ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers.