Swine recombinant IL-17A (Interleukin-17A) protein, AF

IL-17/IL-17A protein, Swine

Interleukin 17-alpha (IL-17A) is a 14.54 kDa cytokine with 131 amino acid residues and is also referred to as CTLA-8. IL-17A is a proinflammatory cytokine mainly expressed in Th 17 cells, NK cells, and innate lymphoid cells (ILCs). After binding to the IL-17 receptor, IL-17A stimulates the production of IL-6, cyclooxygenase-2 (COX-2), and nitric oxide (NO) by activating NF-κB and MAPK signaling pathways. In addition, it also plays an essential role in against infection of extracellular bacteria and fungi by inducing epithelial cells to produce antimicrobial peptides.

Product Info Summary

SKU: PROTB6E279
Size: 5ug,20ug
Origin Species: Swine
Source: Escherichia coli
Application: Cell Culture

Product Name

Swine recombinant IL-17A (Interleukin-17A) protein, AF

View all IL-17/IL-17A recombinant proteins

SKU/Catalog Number

PROTB6E279

Size

5ug,20ug

Tag

His Tag (C-term)

Description

Interleukin 17-alpha (IL-17A) is a 14.54 kDa cytokine with 131 amino acid residues and is also referred to as CTLA-8. IL-17A is a proinflammatory cytokine mainly expressed in Th 17 cells, NK cells, and innate lymphoid cells (ILCs). After binding to the IL-17 receptor, IL-17A stimulates the production of IL-6, cyclooxygenase-2 (COX-2), and nitric oxide (NO) by activating NF-κB and MAPK signaling pathways. In addition, it also plays an essential role in against infection of extracellular bacteria and fungi by inducing epithelial cells to produce antimicrobial peptides.

Storage & Handling

Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months. Avoid repeated freeze/thaw cycles.

Cite This Product

Swine recombinant IL-17A (Interleukin-17A) protein, AF (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTB6E279)

Form

Lyophilized

Formulation

The protein was lyophilized from a 0.2 μm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.

Purity

>98% as determined by SDS-PAGE.

Predicted MW

17.504kDa

Molecular weight

The protein has a calculated MW of 15.81 kDa. The protein migrates as 17-25 kDa under reducing condition (SDS-PAGE analysis).

Activity

Testing in process

Endotoxin

<0.01 EU per 1 μg of the protein by the LAL method.

Amino Acid Sequence

MGIMIPQSPGCPKTEDKNFPQHVRVNLNILNRSTPARRPSDYSKRSTSPWTLQRNEDPERYPSVIWEAKCSHSGCINAEGKEDHHMNSVPIQQEILVLRREPRHCPNSFRLEKVMVTVGCTCVTPIVRHIS with polyhistidine tag at the C-terminus.

Reconstitution

Centrifuge at 3000 rpm for 5 mins before opening. It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 100 μg/mL and incubate the stock solution at room temperature for at least 20 mins to ensure sufficient re-dissolved. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

Validation Images & Assay Conditions

Gene/Protein Information For IL17A (Source: Uniprot.org, NCBI)

Gene Name

IL17A

Full Name

Interleukin-17A

Weight

17.504kDa

Superfamily

IL-17 family

Alternative Names

IL17A IL17A CTLA-8, CTLA8, IL-17, IL-17A, IL17 interleukin 17A interleukin-17A|cytotoxic T-lymphocyte-associated 8|cytotoxic T-lymphocyte-associated protein 8|interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

*If product is indicated to react with multiple species, protein information is based on the gene entry specified above in "Species".

For more info on IL17A, check out the IL17A Infographic

IL17A infographic

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In this infographic, you will see the following information for IL17A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us at [email protected].

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Size

Total: $154

SKU:PROTB6E279

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