Product Info Summary
SKU: | PROTB6E279 |
---|---|
Size: | 5ug,20ug |
Origin Species: | Swine |
Source: | Escherichia coli |
Application: | Cell Culture |
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Product info
Product Name
Swine recombinant IL-17A (Interleukin-17A) protein, AF
View all IL-17/IL-17A recombinant proteins
SKU/Catalog Number
PROTB6E279
Size
5ug,20ug
Tag
His Tag (C-term)
Description
Interleukin 17-alpha (IL-17A) is a 14.54 kDa cytokine with 131 amino acid residues and is also referred to as CTLA-8. IL-17A is a proinflammatory cytokine mainly expressed in Th 17 cells, NK cells, and innate lymphoid cells (ILCs). After binding to the IL-17 receptor, IL-17A stimulates the production of IL-6, cyclooxygenase-2 (COX-2), and nitric oxide (NO) by activating NF-κB and MAPK signaling pathways. In addition, it also plays an essential role in against infection of extracellular bacteria and fungi by inducing epithelial cells to produce antimicrobial peptides.
Storage & Handling
Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months. Avoid repeated freeze/thaw cycles.
Cite This Product
Swine recombinant IL-17A (Interleukin-17A) protein, AF (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTB6E279)
Form
Lyophilized
Formulation
The protein was lyophilized from a 0.2 μm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.
Purity
>98% as determined by SDS-PAGE.
Predicted MW
17.504kDa
Molecular weight
The protein has a calculated MW of 15.81 kDa. The protein migrates as 17-25 kDa under reducing condition (SDS-PAGE analysis).
Activity
Testing in process
Endotoxin
<0.01 EU per 1 μg of the protein by the LAL method.
Amino Acid Sequence
MGIMIPQSPGCPKTEDKNFPQHVRVNLNILNRSTPARRPSDYSKRSTSPWTLQRNEDPERYPSVIWEAKCSHSGCINAEGKEDHHMNSVPIQQEILVLRREPRHCPNSFRLEKVMVTVGCTCVTPIVRHIS with polyhistidine tag at the C-terminus.
Reconstitution
Centrifuge at 3000 rpm for 5 mins before opening. It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 100 μg/mL and incubate the stock solution at room temperature for at least 20 mins to ensure sufficient re-dissolved. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.
Assay dilution & Images
Validation Images & Assay Conditions
Click image to see more details
SDS- PAGE analysis of recombinant swine IL-17A
Protein Target Info & Infographic
Gene/Protein Information For IL17A (Source: Uniprot.org, NCBI)
Gene Name
IL17A
Full Name
Interleukin-17A
Weight
17.504kDa
Superfamily
IL-17 family
Alternative Names
IL17A IL17A CTLA-8, CTLA8, IL-17, IL-17A, IL17 interleukin 17A interleukin-17A|cytotoxic T-lymphocyte-associated 8|cytotoxic T-lymphocyte-associated protein 8|interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
*If product is indicated to react with multiple species, protein information is based on the gene entry specified above in "Species".For more info on IL17A, check out the IL17A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IL17A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us at [email protected].
Specific Publications For Swine recombinant IL-17A (Interleukin-17A) protein, AF (PROTB6E279)
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