Interleukin-17A Antibodies

Interleukin-17A (IL17A)

Ligand for IL17RA and IL17RC (PubMed:17911633).

The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971).

Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). .

Gene Information

Human
Gene Name:	IL17A
Uniprot:	Q16552
Entrez:	3605

Family

Belongs to:
IL-17 family

Alternative Names

CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A

Molecular Weight

Mass (kDA):
17.504 kDA

Genomic Context

Human
Location:	6p12.2
Sequence:	6; NC_000006.12 (52186375..52190638)

Tissue Specificity

Restricted to activated memory T-cells.

Subcellular Localizations

Secreted.

Diseases

• Inflammation
• Autoimmune Reaction
• Autoimmune Diseases
• Arthritis
• Asthma
• Rheumatoid Arthritis
• Colitis
• Experimental Autoimmune Encephalomyelitis
• Malignant Neoplasms
• Encephalomyelitis
• Intestinal Diseases
• Infective Disorder
• Pneumonia

• Autoimmunity
• Crohn Disease
• Neoplasms
• Inflammatory Bowel Diseases
• Atherosclerosis
• Ulcer
• Psoriasis

Interacting Proteins

• DPH2

Pathways

• Pathogenesis
• Secretion
• Immune Response
• Cytokine Production
• Cell Differentiation
• Methylation
• Cell Proliferation
• Inflammatory Response
• Chemotaxis
• Adaptive Immune Response
• T Cell Differentiation
• Sensitization
• T Cell Proliferation

• Cell Development
• Cell Activation
• T Cell Activation
• Dna Methylation
• Hypersensitivity
• Demethylation
• Cell Growth

PTMs

• Methylation
• Phosphorylation

• Demethylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL17A

Best Uses Of The IL17A Marker

If you're looking for a method to better understand the function of the IL17A marker within the immune system, read this article. This article will give an extensive overview of IL-17A and its ligand and how it affects the signaling process in cells. It is important to recognize that this marker is not just for humans. Numerous species and their applications are also useful to scientists worldwide.

IL-17A

The IL-17A gene encodes an inflammatory cell cytokine. It regulates the activity of NF-kappaB and mitogen-activated protein kinases. It is also involved in the regulation of antimicrobial determinants and is involved in the pathology associated with autoimmune diseases. Boster Bio tested the IL-17A antibody for specificity and affinity against the IL-17A protein.

The IL-17A bioassay is a test for the cytokine levels of single cells. This information can be used to guide strategies for the delivery of vaccines. To identify single cells that express IL-17A Boster Bio's ELISpot is a great choice. Flow cytometry also provides additional information, including the phenotype of cells. Boster Bio used transfected CHO cells as stable IL-17A expressers to screen the IL-17A mabs against a panel of bovine cell lines. Both rovIL-17A (both made from E. coli) were used in the mabs.

TNF-alpha is also known as the IL-17A gene. Human and ovine mRNAs and CDNA sequences are available for comparison. Sequences of the IL-17A protein are available in databases that are open to the public, which are an advantage for researchers. Researchers can identify the gene that encoding IL-17A by using a cDNA/mRNA mRNA template.

The IL-17A gene is used in a number of uses, including in the production of biopharmaceuticals and vaccines. It has been studied in ruminant ruminants that are farmed species, as well as in liposomal vaccine preparations. It has been proven to be effective in animal models and its most effective uses are now apparent. It is time to begin using bovine IL-17A in clinical settings.

IL-17RD

The antibody IL-17RD is an innovative one to the inflammatory cytokine TNF-a. Its ECD hinders tumor formation and reduces the inflammatory response. The boster bio version is a liquid form of the cytokine that is utilized in Boster Bio's exclusive psoriasis formulation. This antibody has shown affinity and specificity to TNF-a.

The IL-17RD can be found in cell culture and plasma supernatates. This antibody can detect human IL-17RD inside heparin-treated cells as well as in serum or plasma. Boster Bio's IL-17RD is used in combination with mouse, human and rats' samples. Its ph is less than 0.01.

Scientists were successful in separating IL-17RD with a boster protein trap column. They then further isolated the protein using standard techniques of chromatography. Scientists from all over world can benefit from the boster protein capture technique. It could change the way scientists study TNF-a-induced inflammatory responses. However, it comes with limitations. It is essential to understand the mechanism of action of boster bio.

Researchers have discovered that sIL-17RD blocks TNFRs and has helped to determine its effectiveness as a treatment for RA. Combining immunosuppression with sIL-17RD inhibition can stop arthritis. This research demonstrates that there is a therapeutic benefit to boster bio's component. If you're in search of an innovative treatment, Boster Bio has IL-17RD.

IL-17RA ligand

The Boster Bio IL-17RA Lign is a recombinant proteins made from human IL-17RA. It is characterized by the sequence domain 33-320 aa. It is suitable for SDS-PAGE and is stored at 2-8 degrees Celsius for a week. For longer storage, you can aliquot the protein and store at -20 to -80degC. Additionally boster ligands provide credits for all researchers worldwide.

The cytokine IL-17RA works by synergy with other cytokines. It stabilizes mRNA transcripts that are derived from other inflammatory stimuli that are strong. It activates the kinase IKKi which phosphorylates ACT1. It also connects to TRAF2 to stop destruction of their transcripts. These proteins cooperate to regulate the NFKB signaling pathway.

The ARS014.Abd Ligands bind to IL-17RA by using docking. In the laboratory, this ligand blocks the binding of IL-17A the IL-17RA. The ARS004 protein is immunosuppressive. It blocks IL-17A binding. This is in line with cell surface competition binding tests conducted on THP-1 cells. It also strongly confirms LigandTracer ligand affinity for HaCaT Keratinocytes. It also shows a slow dissociation with the cell-surface receptor.

Antibodies to IL-17RA are highly specific to this cytokine. Boster Bio IL-17RA ligand binds the IL-17RA protein to which it reacts with human receptor. The IL-17RA-specific ligand is available for purchase and is made from mouse IL-17RA. It is tested in IF, IHC, and WB. It is delivered in PBS containing 0.02 percent sodium azide.

Signaling via the IL-17A

Researchers have demonstrated that IL-17A-mediated signaling by B lymphocytes enhances the function of NK cells as well as the release of GM-CSF to fight fungal infections in a study that was recently published. The absence of IL-17A in mice dramatically reduced the amount and growth of metastatic nodules and lungs in the liver and the lungs. These findings could have important implications in the treatment of cancers as well as viral infections.

In addition, anti-IL-17A treatment improved the results of Morris water maze and fear memory tests in anesthetized aged rats. It also significantly reduced post-operative cognitive impairment in elderly rats anesthetized by sevoflurane. Additionally, these studies show that treatment with anti-IL-17A reduces the damage caused by sevoflurane anesthesia.

The study has also proven that blocking IL-17A can increase the immune response to inflammatory conditions and tumors. This means that blocking the expression of IL-17A could aid in treating large granular tumors and inflammatory immune-mediated diseases. It is not clear whether blocking IL-17A in these situations is efficient. Therefore, further research is needed to better comprehend how IL-17A changes the polarity of the immune cells.

In addition, it blocks the IL-15-mediated Blimp-1 up-regulation, IL-17A may also regulate the production of IL-15 in Boster Bio. Therefore, the innate immune response against bacteria that are resistant to antibiotics is based on crosstalk between inflammatory monocytes and lymphocytes that originate from IL-17A and TNF. This interaction also helps promote the clearance of pneumonia.

IFN-g

The cytokine called IL17A is a signaling agent that can be used in many places. The IL17A marker is produced by macrophages that are activated in a different way and their actions controlled by cytokines. This molecule is used to stimulate collagen production and boost cell proliferation. It is important to note that this molecule has a different phenotype depending upon the stimuli it is activated. Therefore it is important to understand how IL17A functions.

Interleukin-17A, a protein, is encoded by the IL17A gene. This protein is produced by activated T cells and regulates the activity of the NF-kappaB and mitogen-activated proteinkinases. It also promotes the expression of IL6 and nitric oxide in cells, which are linked to various diseases like multiple sclerosis and psoriasis. Boster Bio: Best Uses Of The IL17A Marker

The degree of M. bovis infections in cattle is related to IL-17 mRNA expression. It could therefore be used as a biomarker to protect against bovine tuberculosis. Although the IL-17A marker has not yet been widely used in diagnostic procedures it has shown potential. It is not only a powerful biomarker of bovine protection against bovine tuberculosis, it also helps in testing the effectiveness of a vaccine.

IL-10

To detect the cytokine IL-17A A scFv was made with four different anti-IL-17A antibodies. Clone Ap1733 neutralizes IL-17A homodimer and the soluble receptor in humans. Clone AP2350 also neutralizes the human IL-23 receptor. All antibodies were tested in duplicate to confirm the clonal reactivity.

This antibody also blocks IL-17A which causes ig classes to change in B cells. Both the IL-10 as well as IL-17A markers have high affinity for the ig class. This reagent is available at Jackson Laboratories. Jay K. Kolls, Professor at the Louisiana State University Health Sciences Center created the IL-17RA KO mice. The Harvard Institutes of Medicine kept the animals in a clean, germ-free environment throughout all animal experiments. The Harvard Medical School's Standing Committee on Animals ensures that ethical standards are maintained to a high standard.

The most well-known antibodies to detect the inflammatory cytokines are called IL-10 and IL17A. Both IL-10A and IL17A play a significant role in the regulation of intestinal immune responses. Their role in preventing the development of IBD is still not fully understood. Boster Bio has the best anti-cytokine available and is rapidly growing.