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Product Info Summary
| SKU: | PROTQ9XTA1 |
|---|---|
| Size: | 5ug,20ug |
| Origin Species: | Feline |
| Source: | HEK293 cell |
| Application: | Cell Culture |
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Product info
Product Name
Feline recombinant CTLA-4 protein, AF
View all CTLA-4 recombinant proteins
SKU/Catalog Number
PROTQ9XTA1
Size
5ug,20ug
Tag
His Tag (C-term)
Description
CTLA-4 is a protein belonging to the immunoglobulin superfamily and the CD28 receptor family. It interacts with CD80 (B7-1) and CD86 (B7-2) to transmit inhibitory signals to T cells, in contrast to CD28, which sends stimulatory signals. This receptor is also found within regulatory T cells, where it plays a vital role in their functions. CTLA-4 is a key regulator of T cell activation, making it an appealing candidate for autoimmune disease therapy and cancer immunotherapy. Recent evidence further highlights its importance in the function and balance of regulatory T cells (Treg).
Storage & Handling
Lyophilized protein should be stored at -20°C for 1 year. Upon reconstitution, store at 2°C to 8°C for up to 1 week. Further dilute in a buffer containing a carrier protein or stabilizer (e.g. 0.1% BSA, 10%FBS, 5%HSA or 5% trehalose solution), protein aliquots should be stored at -20°C or -80°C for 3-6 months. Avoid repeated freeze/thaw cycles.
Cite This Product
Feline recombinant CTLA-4 protein, AF (Boster Biological Technology, Pleasanton CA, USA, Catalog # PROTQ9XTA1)
Form
Lyophilized
Formulation
The protein was lyophilized from a 0.2 μm filtered solution containing 1X PBS, pH 7.4. If you have any concerns or special requirements, please confirm with us.
Purity
>90% as determined by SDS-PAGE.
Predicted MW
24.656kDa
Molecular weight
The protein has a calculated MW of 14 kDa. The protein migrates as 18-23 kDa uder reducing condition (SDS-PAGE analysis).
Activity
Testing in process
Endotoxin
<0.1 EU per 1 μg of the protein by the LAL method.
Amino Acid Sequence
A DNA sequence encoding Feline CTLA-4 Protein (#Q9XTA1)(Lys36-Asp161) was expressed with polyhistidine tag at the C-terminus.
Reconstitution
Centrifuge at 3000 rpm for 5 mins before opening. It is recommended to reconstitute the lyophilized protein in sterile H₂O to a concentration not less than 100 μg/mL and incubate the stock solution at room temperature for at least 20 mins to ensure sufficient re-dissolved. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.
Assay dilution & Images
Validation Images & Assay Conditions
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SDS- PAGE analysis of recombinant Feline PD-L1
Protein Target Info & Infographic
Gene/Protein Information For CTLA4 (Source: Uniprot.org, NCBI)
Gene Name
CTLA4
Full Name
Cytotoxic T-lymphocyte protein 4
Weight
24.656kDa
Alternative Names
CD152 CTLA4 ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12 cytotoxic T-lymphocyte associated protein 4 cytotoxic T-lymphocyte protein 4|celiac disease 3|cytotoxic T lymphocyte associated 4 short spliced form|cytotoxic T-lymphocyte-associated serine esterase-4|insulin-dependent diabetes mellitus 12|ligand and transmembrane spliced cytotoxic T lymphocyte associated 4
*If product is indicated to react with multiple species, protein information is based on the gene entry specified above in "Species".For more info on CTLA4, check out the CTLA4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CTLA4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us at [email protected].
Specific Publications For Feline recombinant CTLA-4 protein, AF (PROTQ9XTA1)
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