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CTLA4 Antibodies
AND CTLA4 ELISA kits, CTLA4 Proteins
Many biological assays use antibodies to detect CTLA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CTLA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CTLA4 antibodies...
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CTLA4 Infographic by Boster Bio
All CTLA4 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$499
Cat # EK0717
96 wells/kit, with removable strips.
Cat # EK0717
96 wells/kit, with removable strips.
Human
Flow Cytometry, WB
$523
Cat # M00020-2
100 µl
Cat # M00020-2
100 µl
Mouse
ELISA
$499
Cat # FEK0717
96 wells/kit, with removable strips.
Cat # FEK0717
96 wells/kit, with removable strips.
Mouse
ELISA
$500
Cat # EZ0717
For 5 plates, 96 wells each, reagents only, plates are not included
Cat # EZ0717
For 5 plates, 96 wells each, reagents only, plates are not included
CTLA4 Overview
Facts about Cytotoxic T-lymphocyte protein 4.
Cytotoxic T-lymphocyte protein 4 (CTLA4)
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | CTLA4 |
| Uniprot: | P16410 |
| Entrez: | 1493 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD; CD152 antigen; CD152; CD152IDDM12; CD28; celiac disease 3; CELIAC3; CTLA4; CTLA-4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; ICOS; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Molecular Weight
Mass (kDA):
24.656 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.2 |
| Sequence: | 2; NC_000002.12 (203867771..203873965) |
Tissue Specificity
Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
Diseases
- Autoimmune Reaction
- Autoimmune Diseases
- Neoplasms
- Malignant Neoplasms
- Autoimmunity
- Diabetes Mellitus
- Diabetes Mellitus, Insulin-dependent
- Decreased Immunologic Activity [pe]
- Melanoma
- Inflammation
- Graves Disease
- Arthritis
- Rheumatoid Arthritis
Interacting Proteins
- CD80
- CD86
- PIK3R1
Pathways
- Cell Activation
- T Cell Activation
- Immune Response
- Pathogenesis
- Cell Proliferation
- Secretion
- Cytokine Production
- T Cell Proliferation
- Tolerance Induction
- Cell Death
- T Cell Costimulation
- Sensitization
- Lymphocyte Activation
PTMs
- Phosphorylation
- Glycosylation
- Dephosphorylation
- Methylation
- Citrullination
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTLA4
bosterbio.com/bosterbio-gene-info-cards/CTLA4
References
PMID: 1713603 by Harper K., et al. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location.
PMID: 11735222 by Ling V., et al. Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.