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Key=entity_id, value=54467
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Key=sku, value=EKC2031
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Key=created_at, value=2019-02-12 00:21:00
Key=updated_at, value=2024-09-26 01:01:47
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=FAK (Phospho-Tyr576) Colorimetric Cell-Based ELISA Kit
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Key=free_shipping, value=No
Key=template, value=cell-based-phospho-elisa-kits
Key=price, value=540.0000
Key=weight, value=1.0000
Key=meta_title, value=FAK (Phospho-Tyr576) Colorimetric Cell-Based ELISA Kit Price
Key=meta_description, value=FAK (Phospho-Tyr576) Colorimetric Cell-Based ELISA Kit EKC2031
Key=image, value=/b/o/boster-box.png
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Key=thumbnail, value=/b/o/boster-box.png
Key=url_key, value=fak-phospho-tyr576-colorimetric-cell-based-elisa-kit-ekc2031-boster
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Key=thumbnail_label, value=Boster Kit Box
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Key=size, value=1 kit, containing two 96-well plates and all necessary reagents
Key=gene_full_name, value=Focal adhesion kinase 1
Key=uniprot_id, value=Q05397
Key=assay_range, value=> 5000 cells/well
Key=applications, value=ELISA
Key=reactivity, value=Human, Mouse, Rat
Key=source_company, value=AssayBiotech CBP1115; Cost: 300
Key=molecular_weight, value=119233 MW
Key=product_category, value=Cell-Based ELISA Kits
Key=rating_value, value=100
Key=review_count, value=12
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Key=cj_related_products, value=Anoikis:EK2008|EK1579|EK1596^Endothelial Cell Migration:A01368-1^Platelet Aggregation:EK0840^Tissue Adhesions:A12292
Key=description, value=The FAK (Phospho-Tyr576) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FAK (Phospho-Tyr576) protein expression profile in cells. The kit can be used for measuring the relative amounts of FAK (Phospho-Tyr576) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FAK (Phospho-Tyr576).
Key=short_description, value=The FAK (Phospho-Tyr576) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FAK (Phospho-Tyr576) protein expression profile in cells. The kit can be used for measuring the relative amounts of FAK (Phospho-Tyr576) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FAK (Phospho-Tyr576).
Key=gene_name, value=PTK2
Key=synonyms, value=FADK 1;FAK1;Focal adhesion kinase 1;pp125FAK;Protein- tyrosine kinase 2;PTK2
Key=sample_type, value=Cell lines
Key=kit_components, value=FAK (Phospho-Tyr576)
Key=subcellular_localization, value=Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Constituent of focal adhesions. Detected at microtubules.
Key=tissue_specificity, value=Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level).Ubiquitous.
Key=protein_function, value= Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.
Key=storage, value=Store at 4°C for up to 6 months.
Key=custom_attribute_1, value=FAK
Key=custom_attribute_2, value=Phospho-Tyr576
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