Focal adhesion kinase 1 Antibodies

Focal adhesion kinase 1 (PTK2)

Non-receptor protein-tyrosine kinase which plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Regulates axon development and neuronal cell migration, axon branching and synapse formation; necessary for normal development of the nervous system.

Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors.

Gene Information

Human
Gene Name:	PTK2
Uniprot:	Q05397
Entrez:	5747

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.10; FADK 1; FADK1; FADKFAK-related non-kinase polypeptide; FAK; FAK1FRNK; FAKEC 2.7.10.2; focal adhesion kinase 1; pp125FAK; Protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2; PTK2

Molecular Weight

Mass (kDA):
119.233 kDA

Genomic Context

Human
Location:	8q24.3
Sequence:	8; NC_000008.11 (140657900..141002079, complement)

Tissue Specificity

Detected in B and T-lymphocytes. Isoform 1 and isoform 6 are detected in lung fibroblasts (at protein level). Ubiquitous.

Subcellular Localizations

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Constituent of focal adhesions. Detected at microtubules.

Diseases

• Tissue Adhesions
• Neoplasms
• Malignant Neoplasms
• Cell Invasion
• Neoplasm Metastasis
• Carcinoma
• Neoplasm Invasiveness
• Tumor Angiogenesis
• Malignant Neoplasm Of Breast
• Malignant Paraganglionic Neoplasm
• Mammary Neoplasms
• Cell Transformation, Neoplastic
• Lung Neoplasms

• Melanoma
• Pathologic Neovascularization
• Adenocarcinoma
• Liver Carcinoma
• Malignant Tumor Of Colon
• Malignant Neoplasm Of Prostate
• Colonic Neoplasms

Interacting Proteins

• BCAR1
• CRK
• CRKL
• EGFR
• EPHA2

• ERBB2
• FLT1
• GRB7
• ITGB4
• PIK3R3

• PTPN23
• PTRH2
• PXN
• SH2D2A
• SRC

• Src
• TGFB1I1
• Tgfb1i1
• TNS3
• TP53

Pathways

• Cell Adhesion
• Cell Migration
• Cell Proliferation
• Cell Motility
• Localization
• Angiogenesis
• Cell Growth
• Cell Cycle
• Secretion
• Cell Death
• Wound Healing
• Anoikis
• Pathogenesis

• Chemotaxis
• Cell Differentiation
• Focal Adhesion Assembly
• Integrin Activation
• Tube Formation
• Platelet Aggregation
• Endothelial Cell Migration

PTMs

• Phosphorylation
• Dephosphorylation
• Cleavage
• Ribosylation
• Ubiquitination
• Amidation
• Methylation
• Glycosylation
• Oxidation
• Geranylgeranylation

• Palmitoylation
• Sumoylation
• Phosphorothioation
• Prenylation
• Biotinylation
• Reduction
• Myristoylation
• Demethylation
• Nitrosylation
• Carbamylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTK2

Boster Bio - Best Uses Of The PTK2 Marker

Boster's primary antibodies are extensively used in the research community. This article will help you understand the reasons why boster antibodies are reliable and are used in many different applications. In addition, you'll find out about the history of Steven Boster, who founded the company in 1993. Learn more about the origins of the PTK2 marker. Next, purchase some PTK2 antibodies to help you with your next experiment.

The research community is awestruck by Boster's primary antibody.

Boster Bio has been producing high-affinity antibodies for over two decades. Boster's products have been rigorously validated for use in Western Blotting, Immunohistochemistry, and ELISA, and have received over 29,000 citations. Boster's antibodies are recommended for use in a wide range of scientific applications, including cell imaging, cloning and a range of tissue culture.

The high-affinity and specificity of Rockland antibodies make them perfect for a range of applications, including immunocytochemistry, molecular biology, and virology. The primary antibodies are immunoglobulins. They can be conjugated or conjugated depending on the specific demands of an assay. Conjugated antibodies remove the need for secondary antibodies. Boster is an ISO-9001-certified business.

Different manufacturers might have different standards which can impact the quality and reproducibility of the product. To ensure consistency in quality, ensure that the label is correct. Guidelines for proper application and validation have been set by the International Working Group for Antibody Validation. This is essential when reviewing primary antibodies for research projects. Also, you should look for the International Working Group for Antibody Validation (IWG-ACV) guidelines.

Primarily used antibodies in experiments generally are not suitable for use in clinical. It is important to determine and confirm the antigen to determine the most appropriate antibody for a particular research application. If the primary antibody is unable to attach to the antigen prior to incubation, it will not perform. This can be controlled with genetic manipulation of the antigen protein. Genetically modified animals express the antigen protein within their tissues but not the protein of importance.

Steven Boster's story

The first product was developed in 1993, Steven Boster was known as "he who transforms science into the lavatory". Boster has since developed hundreds of primary antibodies as well as numerous products for IHC. Boster is now the largest catalog antibody manufacturer located in China. PicoKine(tm) is an exclusive ELISA platform developed by Boster's company. It makes use of trade secrets to create high-sensitivity ELISA kit kits.

Steve Boster was born in Joliet (IL) on June 6, 1926. He was a long-time manager in retail sales and served in the U.S. Army. His extended family includes Crystal Boster and Natosha Peck, as well as four brothers and six grandchildren. Sandra Blanton and Tammy Boster were his siblings. He also leaves behind a plethora of nieces and nephews.

His antibodies are employed in a myriad of applications.

His antibodies were adapted for a variety of lab techniques in the 20th century. Kesztyus L. and his colleagues, for example, used co-immunoprecipitation to prove the interaction between myosin and actin in muscle. Solomon Berson and Rosalyn Yalow, on the other, have developed a radioimmunoassay for measuring the amount of insulin in blood plasma.

His antibodies are available for purchase

For many years, Boster Bio has been manufacturing antibodies for researchers. Boster Bio's antibodies and ELISA kit have been tested with real tissue and recombinant proteins to ensure that they interact with the targets. The products manufactured by Boster are in-house and available for purchase. Boster's products undergo rigorous quality testing in its own facilities to make sure they're efficient. Boster also provides custom services and BeNeLux delivery.

Boster Bio also manufactures ELISA kits and ELISA-compatible antibodies to suit various applications. Their kits identify a range of antigens and proteins as well as the cytokines. Boster has over 20 years of experience and over 10,000 scientists from around the world trust it. Boster's Picokine ELISA kits speed up scientific discovery. They are validated and include enough reagents that allow you to run tests of 96. Boster's antibodies can be purchased from tebubio.