WNK4 Antibodies

AND WNK4 ELISA kits, WNK4 Proteins

Many biological assays use antibodies to detect WNK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WNK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WNK4 antibodies...

We validate the specificity of these antibodies to WNK4 by testing them on tissues known to express WNK4 positively and negatively. Browse below to find the WNK4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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WNK4 Infographic by Boster Bio

All WNK4 Products

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Product

Figures

Specificity

Applications

Price

Anti-WNK4 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02438
100ul

WNK4 (NM_032387) Human Over-expression Lysate

Human

$960
Cat # LS065266
100 µg

WNK4 Overview

Facts about Serine/threonine-protein kinase WNK4.

WNK4 3D structure. Source: alphafold

Serine/threonine-protein kinase WNK4 (WNK4)

Serine/threonine kinase that plays an significant role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6.

Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to avoid membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, through a kinase-independent mechanism by which it compels clearance of the protein in the cell surface by clathrin-dependent endocytosis.

Gene Information

Human
Gene Name:	WNK4
Uniprot:	Q96J92
Entrez:	65266

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; PHA2B; PRKWNK4protein kinase, lysine deficient 4; Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; serine/threonine-protein kinase WNK4; WNK lysine deficient protein kinase 4

Molecular Weight

Mass (kDA):
134.739 kDA

Genomic Context


Human

Location:	17q21.2
Sequence:	17; NC_000017.11 (42779701..42797066)

Tissue Specificity

Expressed in kidney, colon and skin.

Subcellular Localizations

Cell junction, tight junction. Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex.