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- Table of Contents
Facts about Septin-9.
May play a role in the internalization of two intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. .
Human | |
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Gene Name: | SEPTIN9 |
Uniprot: | Q9UHD8 |
Entrez: | 10801 |
Belongs to: |
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TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily |
Septin-9
Mass (kDA):
65.401 kDA
Human | |
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Location: | 17q25.3 |
Sequence: | 17; NC_000017.11 (77281499..77500596) |
Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.
Cytoplasm, cytoskeleton. In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
PMID: 10339604 by Osaka M., et al. MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).
PMID: 10987277 by Russell S.E.H., et al. Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors.