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WNK2 Antibodies
AND WNK2 ELISA kits, WNK2 Proteins
Many biological assays use antibodies to detect WNK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with WNK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop WNK2 antibodies...
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WNK2 Overview
Facts about Serine/threonine-protein kinase WNK2.
Serine/threonine-protein kinase WNK2 (WNK2)
Serine/threonine kinase that plays an significant role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively.
Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression.
Gene Information
| Human | |
|---|---|
| Gene Name: | WNK2 |
| Uniprot: | Q9Y3S1 |
| Entrez: | 65268 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; PRK; PRKWNK2; Protein kinase with no lysine 2; SDCCAG43; serine/threonine-protein kinase WNK2; Serologically defined colon cancer antigen 43lysine deficient 2; WNK lysine deficient protein kinase 2
Molecular Weight
Mass (kDA):
242.676 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q22.31 |
| Sequence: | 9; NC_000009.12 (93184156..93327581) |
Tissue Specificity
Expressed in various cancer cell lines (at protein level). Predominantly expressed in heart, brain, skeletal muscle and colon.
Subcellular Localizations
Cytoplasm. Cell membrane.
Diseases
- Hypertensive Disease
- Neoplasms
- Glioma
- Pseudohypoaldosteronism
- Malignant Neoplasms
- Malignant Tumor Of Colon
- Neoplasm Invasiveness
- Carcinoma
- Meningioma
- Hypotension Adverse Event
- Infarction
- Malignant Neoplasm Of Breast
Pathways
- Methylation
- Cell Growth
- Cell Proliferation
- Transport
- Gene Silencing
- Cell Adhesion
- Induction Of Programmed Cell Death
- Regulation Of Macroautophagy
- Cell Migration
- Programmed Cell Death
- Induction Of Apoptosis
- Cellular Homeostasis
- Dna Methylation
PTMs
- Phosphorylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/WNK2
bosterbio.com/bosterbio-gene-info-cards/WNK2
References
PMID: 11571656 by Verissimo F., et al. WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.
PMID: 11280764 by Ito M., et al. Molecular basis of T cell-mediated recognition of pancreatic cancer cells.