MGAT5 Antibodies

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (MGAT5)

Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage into the alpha-linked mannose of biantennary N- linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those located on EGFR, TGFR (TGF- beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003).

Via its role in the biosynthesis of complex N- glycans, plays a significant role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N- glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling.

Gene Information

Human
Gene Name:	MGAT5
Uniprot:	Q09328
Entrez:	4249

Family

Belongs to:
glycosyltransferase 18 family

Alternative Names

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; EC 2.4.1.155; GGNT5; GlcNAc-T V; GNT-VGNT-VA; Mannoside acetylglucosaminyltransferase 5; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; MGAT5; N-Acetylglucosaminyltransferase V; N-acetylglucosaminyl-transferase V

Molecular Weight

Mass (kDA):
84.543 kDA

Genomic Context

Human
Location:	2q21.2-q21.3
Sequence:	2; NC_000002.12 (134119922..134454621)

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.; [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A]: Secreted.

Diseases

• Neoplasms
• Malignant Neoplasms
• Neoplasm Metastasis
• Carcinoma
• Tissue Adhesions
• Sclerosis
• Multiple Sclerosis
• Autoimmune Reaction
• Autoimmunity
• Malignant Neoplasm Of Breast
• Mammary Neoplasms, Experimental
• Autoimmune Diseases

• Cell Invasion
• Encephalomyelitis
• Experimental Autoimmune Encephalomyelitis
• Mammary Neoplasms
• Adenocarcinoma
• Inflammation
• Animal Mammary Neoplasms

Pathways

• Glycosylation
• Endocytosis
• Cell Growth
• Cell Motility
• Cell Proliferation
• Cell Migration
• Protein Glycosylation
• N-glycan Processing
• Cytokine Production
• Pathogenesis
• Transport
• Oncogenesis
• Fucosylation

• Aging
• Proteolysis
• Immune Response
• Hypersensitivity
• Cell Division
• Phagocytosis
• T Cell Proliferation

PTMs

• Glycosylation

• Phosphorylation

• Citrullination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MGAT5

Boster Bio and the MGAT5 Marker

If you have ever wondered how to use the MGAT5 Marker in immunohistochemistry, you're not alone. It can also be used to detect MGAT5. The MGAT5 protein gene is required for the detection of many proteins including TNFalpha. This article will provide background information on Boster Bio and the MGAT5 Marker.

Boster Bio's Anti-TNF Alpha Monoclonal Antibody

The MGAT5 genes is one of the most widely studied markers for TNF. In fact, Boster Bio's Anti-TNF Alpha Monoclonal antibody targets MGAT5. This molecule is unique in that it targets MGAT5. This is good news for patients, who will soon benefit from this treatment.

This marker was used by the research group to identify the specific protein which activates TNF. The findings of the team are described in the book, "An Immunological approach to TNF." Bol, Moerland Moerland, Limou and Van Overmeire, Rocks and Natacha were part of the research team. They also used MGAT5 to identify TNFalpha in human cell lines.

These antibodies have a similar purity and monodispersity to each other. Both of them are produced using a recombinant platform incorporating a publicly available sequence. They are supplied in a research-grade format in PBS buffer containing a preservative. Both biosimilars exhibit similar purity and monodispersity. Band quantification on SDS/PAGE gels shows that the bands of both biosimilars are identical. These data are available on the product information pages.

Because of their high specificity and versatility, these antibodies are vital tools for combating various diseases. They can prevent disease progression and enhance recovery, regardless if there is immunity. They are highly effective against severe COVID-19, CSS. These antibodies are a promising option. This treatment could be the next breakthrough in TNF therapy, as it targets the MGAT5 marker.

Immunohistochemistry, a method of protein detection

The company's products are designed for immunohistochemistry. These antibodies generate visible bands of color, also known as visible proteins. By examining the location of these bands researchers can assess the level of target protein in a tissue or cell. This method is used in clinical immunology laboratories to diagnose and monitor the treatment of autoimmune diseases.

Boster Bio offers IHC for research and diagnostic uses, which facilitates the transfer or assays. The guide provides step-by–step guidance for performing IHC. This includes common problems such as weak staining or high background and non-specific staining. It also includes a comprehensive overview and descriptions of IHC resources including protocols as well as techniques for different types.

Boster Bio's Immunohistochemistry systems can be used to detect proteins within cells, tissues, or tissues. Both methods rely upon secondary antibodies binding to target proteins. These tests are highly sensitive and specific, making them suitable for analyzing protein expression in complex tissue sections. Biochemistry and molecular biology both use immunohistochemistry extensively.

Boster Bio has a wide range of ELISA kits. They include all necessary reagents for an ELISA analysis. Boster Bio is a reliable and trusted supplier of ELISA kit. Boster Bio's Anti-Thrombopoietin Monoclonal Antibody reacts well with human cells and is available in a 100-ul Liquid form. Boster Bio's Anti P53 Tp53 Monoclonal Antibody can also be purchased Lyophilized.