This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
MGAT5 Antibodies
AND MGAT5 ELISA kits, MGAT5 Proteins
Many biological assays use antibodies to detect MGAT5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MGAT5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MGAT5 antibodies...
Previous: CBLIF
Next: SCGB2A2
MGAT5 Infographic by Boster Bio
All MGAT5 Products
Product
Figures
Specificity
Applications
Price
MGAT5 Overview
Facts about Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A.
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A (MGAT5)
Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage into the alpha-linked mannose of biantennary N- linked oligosaccharides (PubMed:10395745, PubMed:30140003). Catalyzes an important step in the biosynthesis of branched, complex-type N-glycans, such as those located on EGFR, TGFR (TGF- beta receptor) and CDH2 (PubMed:10395745, PubMed:22614033, PubMed:30140003).
Via its role in the biosynthesis of complex N- glycans, plays a significant role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5-dependent EGFR N- glycosylation enhances the interaction between EGFR and LGALS3 and thereby prevents rapid EGFR endocytosis and prolongs EGFR signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | MGAT5 |
| Uniprot: | Q09328 |
| Entrez: | 4249 |
Family
| Belongs to: |
|---|
| glycosyltransferase 18 family |
Alternative Names
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase; EC 2.4.1.155; GGNT5; GlcNAc-T V; GNT-VGNT-VA; Mannoside acetylglucosaminyltransferase 5; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase; MGAT5; N-Acetylglucosaminyltransferase V; N-acetylglucosaminyl-transferase V
Molecular Weight
Mass (kDA):
84.543 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q21.2-q21.3 |
| Sequence: | 2; NC_000002.12 (134119922..134454621) |
Subcellular Localizations
Golgi apparatus membrane; Single-pass type II membrane protein.; [Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A]: Secreted.
Diseases
- Neoplasms
- Malignant Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Tissue Adhesions
- Sclerosis
- Multiple Sclerosis
- Autoimmune Reaction
- Autoimmunity
- Malignant Neoplasm Of Breast
- Mammary Neoplasms, Experimental
- Autoimmune Diseases
Pathways
- Glycosylation
- Endocytosis
- Cell Growth
- Cell Motility
- Cell Proliferation
- Cell Migration
- Protein Glycosylation
- N-glycan Processing
- Cytokine Production
- Pathogenesis
- Transport
- Oncogenesis
- Fucosylation
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MGAT5
bosterbio.com/bosterbio-gene-info-cards/MGAT5
References
PMID: 8292036 by Nishikawa A., et al. cDNA cloning and chromosomal mapping of human N- acetylglucosaminyltransferase V+.
PMID: 10395745 by Park C., et al. Characterization of UDP-N-acetylglucosamine: alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B.