VSIR Antibodies

AND VSIR ELISA kits, VSIR Proteins

Many biological assays use antibodies to detect VSIR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with VSIR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop VSIR antibodies...

We validate the specificity of these antibodies to VSIR by testing them on tissues known to express VSIR positively and negatively. Browse below to find the VSIR antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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VSIR Infographic by Boster Bio

All VSIR Products

Product

Figures

Specificity

Applications

Price

Anti-VISTA VSIR Antibody

Human

ELISA, IF, IHC, ICC, WB

$449
Cat # A32320
0.1 mg

Anti-VISTA VSIR Monoclonal Antibody [4C4]

Human

ELISA, Flow Cytometry, IF, IHC-P, ICC, WB

$524
Cat # M32320
0.1 mg

GI24 (C10orf54) (NM_022153) Human Recombinant Protein

$1249
Cat # PROTQ9H7M9
20 µg

Mouse VISTA/B7-H5/PD-1H Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ9D659
Starting from 10ug

GI24 (C10orf54) (NM_022153) Human Over-expression Lysate

Human

$628
Cat # LS064115
100 µg

VSIR Overview

Facts about V-type immunoglobulin domain-containing suppressor of T-cell activation.

VSIR 3D structure. Source: alphafold

V-type immunoglobulin domain-containing suppressor of T-cell activation (VSIR)

Immunoregulatory receptor which inhibits the T-cell reaction (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).

May stimulate MMP14-mediated MMP2 activation (PubMed:20666777). .

Gene Information

Human
Gene Name:	VSIR
Uniprot:	Q9H7M9
Entrez:	64115

Family

Belongs to:

No superfamily

Alternative Names

4632428N05Rik; B7H5; B7-H5; C10orf54; chromosome 10 open reading frame 54; Dies1; Gi24; PD1H; PD-1H; platelet receptor Gi24; PP2135; SISP1; stress induced secreted protein 1; VISTA; VSIR

Molecular Weight

Mass (kDA):
33.908 kDA

Genomic Context


Human

Location:	10q22.1
Sequence:	10; NC_000010.11 (71747556..71773520, complement)

Tissue Specificity

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

Research Areas

Cancer
Immunology

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/VSIR

References

PMID: 20666777 by Sakr M.A., et al. GI24 enhances tumor invasiveness by regulating cell surface membrane- type 1 matrix metalloproteinase.

PMID: 24691993 by Lines J.L., et al. VISTA is an immune checkpoint molecule for human T cells.